Your browser doesn't support javascript.
loading
MAGI2-AS3 inhibits breast cancer by downregulating DNA methylation of MAGI2.
Xu, Xiaolong; Yuan, Xiaoning; Ni, Jiali; Guo, Jing; Gao, Yang; Yin, Weinan; Li, Feng; Wei, Lei; Zhang, Jingwei.
Afiliação
  • Xu X; Department of Pathology and Pathophysiology, Hubei Provincial Key Laboratory of Developmentally Originated Disease, School of Basic Medical Sciences, Wuhan University, Wuhan, Hubei, China.
  • Yuan X; Department of Pathology and Pathophysiology, Hubei Provincial Key Laboratory of Developmentally Originated Disease, School of Basic Medical Sciences, Wuhan University, Wuhan, Hubei, China.
  • Ni J; Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
  • Guo J; Department of Genetics, School of Basic Medical Sciences, Wuhan University, Wuhan, Hubei, China.
  • Gao Y; Department of Pathology and Pathophysiology, Hubei Provincial Key Laboratory of Developmentally Originated Disease, School of Basic Medical Sciences, Wuhan University, Wuhan, Hubei, China.
  • Yin W; Department of Pathology and Pathophysiology, Hubei Provincial Key Laboratory of Developmentally Originated Disease, School of Basic Medical Sciences, Wuhan University, Wuhan, Hubei, China.
  • Li F; Department of Genetics, School of Basic Medical Sciences, Wuhan University, Wuhan, Hubei, China.
  • Wei L; Department of Pathology and Pathophysiology, Hubei Provincial Key Laboratory of Developmentally Originated Disease, School of Basic Medical Sciences, Wuhan University, Wuhan, Hubei, China.
  • Zhang J; Department of Breast and Thyroid Surgery, Zhongnan Hospital, Hubei Key Laboratory of Tumor Biological Behaviors, Hubei Cancer Clinical Study Center, Wuhan University, Wuhan, Hubei, China.
J Cell Physiol ; 236(2): 1116-1130, 2021 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-32730644
ABSTRACT
Breast cancer is one of the most threatening diseases for women. Long noncoding RNAs were reported to be involved in breast cancer development. In this study, we analyzed The Cancer Genome Atlas breast cancer tissue high-throughput sequencing data and screened and validated the low-expressing long noncoding RNA named MAGI2-AS3. Through gene coexpression analysis, we found that MAGI2-AS3 has a good expression correlation with MAGI2. Overexpression of MAGI2-AS3 or MAGI2 in breast cancer cells MCF-7 would inhibit the Wnt/ß-catenin pathway and inhibit cell proliferation and migration. Gene structure and DNA methylation analysis results indicated that MAGI2-AS3 may act as a cis-acting regulatory element downregulating the DNA methylation level of the MAGI2 promoter region, and the DNA demethylase TET1 inhibitor can reverse MAGI2-AS3 overexpression caused upregulation of MAGI2 and cellular effects. Our findings reveal the role of MAGI2-AS3 in breast cancer and provide potential novel therapeutic targets for metastatic breast cancer intervention.
Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Idioma: Inglês Revista: J Cell Physiol Ano de publicação: 2021 Tipo de documento: Artigo País de afiliação: China

Similares

MEDLINE

...
LILACS

LIS

Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Idioma: Inglês Revista: J Cell Physiol Ano de publicação: 2021 Tipo de documento: Artigo País de afiliação: China