Your browser doesn't support javascript.
loading
Antimicrobial resistance and virulence determinants in coagulase-negative staphylococci isolated mainly from preterm neonates.
Al-Haqan, Aishah; Boswihi, Samar S; Pathan, Seema; Udo, Edet E.
Afiliação
  • Al-Haqan A; Microbiology Laboratory, Maternity Hospital, Kuwait city, Kuwait.
  • Boswihi SS; Department of Microbiology, Faculty of Medicine, Kuwait University, Kuwait city, Kuwait.
  • Pathan S; Microbiology Laboratory, Maternity Hospital, Kuwait city, Kuwait.
  • Udo EE; Department of Microbiology, Faculty of Medicine, Kuwait University, Kuwait city, Kuwait.
PLoS One ; 15(8): e0236713, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32750089
ABSTRACT
Coagulase-negative staphylococci (CoNS) are the most common isolates from blood culture in neonates resulting in high mortality and morbidity. This study investigated CoNS obtained from blood cultures of neonates for antibiotic resistance and virulence factors, and possible association with inflammatory response (C-reactive protein). A total of 93 CoNS isolates were collected from 76 blood cultures of neonates at the Maternity hospital in Kuwait in a six-month period and investigated for susceptibility to antibiotics, carriage of staphylococcal cassette chromosome mec (SCCmec), and virulence-associated genes. The 93 CoNS isolates consisted of S. epidermidis (76; 81.7%), S. capitis (12; 12.9%), S. hominis (2; 2.1%), S. warneri (2; 2.1%) and S. haemolyticus (1; 1.0%). Eighty-six (92.4%) of the isolates were resistant to cefoxitin (MR-CoNS) while 49 (52.7%) expressed multi-antibiotic resistance. The methicillin-resistant isolates (MR-CoNS) carried SCCmec III, SCCmec IVa and four combinations of SCCmec types including SCCmec types I+IVa (one S. warneri and 25 S. epidermidis isolates), types I+III (one S. epidermidis isolate), types III+IVa (six S. epidermidis isolates) and types I+III+IVa (one S. epidermidis isolate). The most common virulence-related genes were icaC, seb, arc detected in 69.7%, 60.5%, 40.8% of the isolates respectively. Two isolates were positive for tst1. No association between C-reactive protein and antibiotic resistance or virulence factors was established. This study revealed that S. epidermidis carrying different SCCmec genetic elements, was the dominant CoNS species isolated from neonatal blood cultures with 90.3% and 36.6% of the isolates positive for genes for biofilm and ACME production respectively.
Assuntos
Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Infecções Estafilocócicas / Staphylococcus / Recém-Nascido Prematuro / Farmacorresistência Bacteriana / Antibacterianos Tipo de estudo: Estudo observacional / Fatores de risco Limite: Feminino / Humanos / Masculino / Recém-Nascido País/Região como assunto: Ásia Idioma: Inglês Revista: PLoS One Assunto da revista: Ciência / Medicina Ano de publicação: 2020 Tipo de documento: Artigo País de afiliação: Kuait

Similares

MEDLINE

...
LILACS

LIS

Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Infecções Estafilocócicas / Staphylococcus / Recém-Nascido Prematuro / Farmacorresistência Bacteriana / Antibacterianos Tipo de estudo: Estudo observacional / Fatores de risco Limite: Feminino / Humanos / Masculino / Recém-Nascido País/Região como assunto: Ásia Idioma: Inglês Revista: PLoS One Assunto da revista: Ciência / Medicina Ano de publicação: 2020 Tipo de documento: Artigo País de afiliação: Kuait
...