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Intake of Dietary Fruit, Vegetables, and Fiber and Risk of Colorectal Cancer According to Molecular Subtypes: A Pooled Analysis of 9 Studies.
Hidaka, Akihisa; Harrison, Tabitha A; Cao, Yin; Sakoda, Lori C; Barfield, Richard; Giannakis, Marios; Song, Mingyang; Phipps, Amanda I; Figueiredo, Jane C; Zaidi, Syed H; Toland, Amanda E; Amitay, Efrat L; Berndt, Sonja I; Borozan, Ivan; Chan, Andrew T; Gallinger, Steven; Gunter, Marc J; Guinter, Mark A; Harlid, Sophia; Hampel, Heather; Jenkins, Mark A; Lin, Yi; Moreno, Victor; Newcomb, Polly A; Nishihara, Reiko; Ogino, Shuji; Obón-Santacana, Mireia; Parfrey, Patrick S; Potter, John D; Slattery, Martha L; Steinfelder, Robert S; Um, Caroline Y; Wang, Xiaoliang; Woods, Michael O; Van Guelpen, Bethany; Thibodeau, Stephen N; Hoffmeister, Michael; Sun, Wei; Hsu, Li; Buchanan, Daniel D; Campbell, Peter T; Peters, Ulrike.
Afiliação
  • Hidaka A; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington. akihisahidaka@gmail.com.
  • Harrison TA; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
  • Cao Y; Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St Louis, Missouri.
  • Sakoda LC; Alvin J. Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine, St. Louis, Missouri.
  • Barfield R; Division of Gastroenterology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri.
  • Giannakis M; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
  • Song M; Division of Research, Kaiser Permanente Northern California, Oakland, California.
  • Phipps AI; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
  • Figueiredo JC; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
  • Zaidi SH; Departments of Epidemiology and Nutrition, Harvard T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts.
  • Toland AE; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
  • Amitay EL; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
  • Berndt SI; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
  • Borozan I; Department of Epidemiology, University of Washington, Seattle, Washington.
  • Chan AT; Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California.
  • Gallinger S; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California.
  • Gunter MJ; Ontario Institute for Cancer Research, Toronto, Ontario, Canada.
  • Guinter MA; Departments of Cancer Biology and Genetics and Internal Medicine, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio.
  • Harlid S; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Hampel H; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
  • Jenkins MA; Ontario Institute for Cancer Research, Toronto, Canada.
  • Lin Y; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
  • Moreno V; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
  • Newcomb PA; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
  • Nishihara R; Broad Institute of Harvard and MIT, Cambridge, Massachusetts.
  • Ogino S; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts.
  • Obón-Santacana M; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts.
  • Parfrey PS; Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.
  • Potter JD; Nutrition and Metabolism Section, International Agency for Research on Cancer, World Health Organization, Lyon, France.
  • Slattery ML; Behavioral and Epidemiology Research Group, American Cancer Society, Atlanta, Georgia.
  • Steinfelder RS; Department of Radiation Sciences, Oncology Unit, Umeå University, Umeå, Sweden.
  • Um CY; Departments of Cancer Biology and Genetics and Internal Medicine, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio.
  • Wang X; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.
  • Woods MO; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
  • Van Guelpen B; Oncology Data Analytics Program, Catalan Institute of Oncology-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.
  • Thibodeau SN; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
  • Hoffmeister M; Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain.
  • Sun W; ONCOBEL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain.
  • Hsu L; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
  • Buchanan DD; School of Public Health, University of Washington, Seattle, Washington.
  • Campbell PT; Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
  • Peters U; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
Cancer Res ; 80(20): 4578-4590, 2020 Oct 15.
Artigo em Inglês | MEDLINE | ID: mdl-32816852
ABSTRACT
Protective associations of fruits, vegetables, and fiber intake with colorectal cancer risk have been shown in many, but not all epidemiologic studies. One possible reason for study heterogeneity is that dietary factors may have distinct effects by colorectal cancer molecular subtypes. Here, we investigate the association of fruit, vegetables, and fiber intake with four well-established colorectal cancer molecular subtypes separately and in combination. Nine observational studies including 9,592 cases with molecular subtypes for microsatellite instability (MSI), CpG island methylator phenotype (CIMP), and somatic mutations in BRAF and KRAS genes, and 7,869 controls were analyzed. Both case-only logistic regression analyses and polytomous logistic regression analyses (with one control set and multiple case groups) were used. Higher fruit intake was associated with a trend toward decreased risk of BRAF-mutated tumors [OR 4th vs. 1st quartile = 0.82 (95% confidence interval, 0.65-1.04)] but not BRAF-wildtype tumors [1.09 (0.97-1.22); P difference as shown in case-only analysis = 0.02]. This difference was observed in case-control studies and not in cohort studies. Compared with controls, higher fiber intake showed negative association with colorectal cancer risk for cases with microsatellite stable/MSI-low, CIMP-negative, BRAF-wildtype, and KRAS-wildtype tumors (P trend range from 0.03 to 3.4e-03), which is consistent with the traditional adenoma-colorectal cancer pathway. These negative associations were stronger compared with MSI-high, CIMP-positive, BRAF-mutated, or KRAS-mutated tumors, but the differences were not statistically significant. These inverse associations for fruit and fiber intake may explain, in part, inconsistent findings between fruit or fiber intake and colorectal cancer risk that have previously been reported.

SIGNIFICANCE:

These analyses by colorectal cancer molecular subtypes potentially explain the inconsistent findings between dietary fruit or fiber intake and overall colorectal cancer risk that have previously been reported.
Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Tipo de estudo: Estudo de etiologia / Estudo observacional / Fatores de risco Idioma: Inglês Revista: Cancer Res Ano de publicação: 2020 Tipo de documento: Artigo

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Tipo de estudo: Estudo de etiologia / Estudo observacional / Fatores de risco Idioma: Inglês Revista: Cancer Res Ano de publicação: 2020 Tipo de documento: Artigo