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In vivo imaging characterization of basal cell carcinoma cutaneous response to high dose ionizing radiation therapy: A prospective study of reflectance confocal microscopy, dermoscopy, and ultrasound.
Navarrete-Dechent, Cristian; Cordova, Miguel; Liopyris, Konstantinos; Aleissa, Saud; Rajadhyaksha, Milind; Cohen, Gil'ad; Marghoob, Ashfaq A; Rossi, Anthony M; Barker, Christopher A.
Afiliação
  • Navarrete-Dechent C; Department of Dermatology, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile; Dermatology Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
  • Cordova M; Dermatology Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
  • Liopyris K; Dermatology Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
  • Aleissa S; Dermatology Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
  • Rajadhyaksha M; Dermatology Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
  • Cohen G; Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Marghoob AA; Dermatology Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
  • Rossi AM; Dermatology Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
  • Barker CA; Brachytherapy Service, Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address: barkerc@mskcc.org.
J Am Acad Dermatol ; 2020 Aug 19.
Artigo em Inglês | MEDLINE | ID: mdl-32827607
ABSTRACT

BACKGROUND:

Radiation therapy (RT) is a treatment option for selected skin cancers. The histologic effects of RT on normal skin or skin cancers are not well-characterized. Dermoscopy, high frequency ultrasonography (HFUS), and reflectance confocal microscopy (RCM) are non-invasive imaging modalities that may help characterize RT response.

OBJECTIVES:

To describe changes in the tumor and surrounding skin of basal cell carcinoma (BCC) patients treated with RT.

METHODS:

The study was conducted between 2014-2018. Patients with biopsy-proven BCCs were treated with 42 Gy in 6 fractions using a commercially available brachytherapy device. Dermoscopy, HFUS, RCM were performed before treatment, 6 weeks, 3 months and 12 months after RT.

RESULTS:

137 imaging assessments (RCM + dermoscopy + HFUS) were performed in 12 patients. Presence of BCC-specific features were present in 81.8%, 91% and 17% of patients imaged with dermoscopy, RCM and HFUS at baseline, prior to treatment. After treatment, resolution of these features was noted in 33.4%, 91.7%, and 100% of patients imaged with the respective modalities. No recurrences were seen after 31.7 months mean follow-up.

LIMITATIONS:

Small sample size and no histopathological correlation.

CONCLUSION:

Dermoscopy and HFUS were not as reliable as RCM at characterizing BCCs RT response.
Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Tipo de estudo: Estudo observacional Idioma: Inglês Ano de publicação: 2020 Tipo de documento: Artigo País de afiliação: Estados Unidos

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Tipo de estudo: Estudo observacional Idioma: Inglês Ano de publicação: 2020 Tipo de documento: Artigo País de afiliação: Estados Unidos