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Betulinic acid inhibits cell proliferation and migration in gastric cancer by targeting the NF-κB/VASP pathway.
Chen, Xiang; Yuan, Xiao-Ning; Zhang, Zun; Gong, Peng-Ju; Yin, Wei-Nan; Jiang, Qi; Xu, Jingjing; Xu, Xiao-Long; Gao, Yang; Chen, Wen-Li; Chen, Fang-Fang; Tian, Yi-Hao; Wei, Lei; Zhang, Jing-Wei.
Afiliação
  • Chen X; Department of Breast and Thyroid Surgery, Zhongnan Hospital, Hubei Key Laboratory of Tumor Biological Behaviors, Hubei Cancer Clinical Study Center, Wuhan University, Wuhan, 430071, Hubei, China; Department of Pathology, Central Theater Command General Hospital, People's Liberation Army of China, Wu
  • Yuan XN; Department of Pathology and Pathophysiology, School of Basic Medical Sciences, Wuhan University, Wuhan, 430071, Hubei, China.
  • Zhang Z; Department of Breast and Thyroid Surgery, Renmin Hospital, Hubei Cancer Clinical Study Center, Wuhan University, Wuhan, 430071, Hubei, China.
  • Gong PJ; Department of Breast and Thyroid Surgery, Zhongnan Hospital, Hubei Key Laboratory of Tumor Biological Behaviors, Hubei Cancer Clinical Study Center, Wuhan University, Wuhan, 430071, Hubei, China.
  • Yin WN; Department of Pathology and Pathophysiology, School of Basic Medical Sciences, Wuhan University, Wuhan, 430071, Hubei, China.
  • Jiang Q; Department of Pathology and Pathophysiology, School of Basic Medical Sciences, Wuhan University, Wuhan, 430071, Hubei, China.
  • Xu J; Department of Breast and Thyroid Surgery, Zhongnan Hospital, Hubei Key Laboratory of Tumor Biological Behaviors, Hubei Cancer Clinical Study Center, Wuhan University, Wuhan, 430071, Hubei, China.
  • Xu XL; Department of Pathology and Pathophysiology, School of Basic Medical Sciences, Wuhan University, Wuhan, 430071, Hubei, China.
  • Gao Y; Department of Pathology and Pathophysiology, School of Basic Medical Sciences, Wuhan University, Wuhan, 430071, Hubei, China.
  • Chen WL; Division of Nephrology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430014, Hubei, China.
  • Chen FF; Department of Breast and Thyroid Surgery, Zhongnan Hospital, Hubei Key Laboratory of Tumor Biological Behaviors, Hubei Cancer Clinical Study Center, Wuhan University, Wuhan, 430071, Hubei, China.
  • Tian YH; Department of Pathology and Pathophysiology, School of Basic Medical Sciences, Wuhan University, Wuhan, 430071, Hubei, China.
  • Wei L; Department of Pathology and Pathophysiology, School of Basic Medical Sciences, Wuhan University, Wuhan, 430071, Hubei, China.
  • Zhang JW; Department of Breast and Thyroid Surgery, Zhongnan Hospital, Hubei Key Laboratory of Tumor Biological Behaviors, Hubei Cancer Clinical Study Center, Wuhan University, Wuhan, 430071, Hubei, China. Electronic address: zjwzhang68@whu.edu.cn.
Eur J Pharmacol ; 889: 173493, 2020 Dec 15.
Artigo em Inglês | MEDLINE | ID: mdl-32860808
ABSTRACT
Gastric cancer (GC) is one of the most common malignant neoplasms of the digestive system, with China leading in terms of morbidity and mortality rates. Betulinic acid (BA) is a widely-occurring pentacyclic triterpenoid that has been reported to exhibit potent anti-inflammatory, antioxidant, and antitumor activities. BA can combat tumors by inducing apoptosis, regulating cell cycle, and inhibiting autophagy, but its mechanism of action in the context of GC is unclear. A preliminary study found that higher expression of vasodilator-stimulated phosphoprotein (VASP) was correlated with migration in the GC cell line. In this study, BGC-823 cells and MNK45 cells were treated with BA for investigating its effect on the proliferation and migration of cells. Moreover, the expression of VASP and upstream signal molecules were also investigated in this background. The results showed BA could inhibit the proliferation and migration the GC cells. Furthermore, NF-κB acted as a transcription factor to upregulate VASP expression. Moreover, BA could downregulate the expression of VASP at the protein and mRNA level by inhibiting NF-κB activity. In conclusion, these results suggest that BA could inhibit the expression of VASP by negatively regulating NF-κB, thereby inhibiting the proliferation and migration of the GC cells. Our study provides a theoretical basis for exploring the molecular mechanism underlying BA-induced inhibition of proliferation and migration in GC cells.
Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Idioma: Inglês Revista: Eur J Pharmacol Ano de publicação: 2020 Tipo de documento: Artigo

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Idioma: Inglês Revista: Eur J Pharmacol Ano de publicação: 2020 Tipo de documento: Artigo
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