Your browser doesn't support javascript.
loading
Squamous cell carcinoma in situ upstaging is not frequent in the nail unit: a tertiary cancer center experience.
Aleissa, Saud; Cowen, Emily; Navarrete-Dechent, Cristian; Busam, Klaus J; Rossi, Anthony M; Lee, Erica H; Nehal, Kishwer S.
Afiliação
  • Aleissa S; Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, 530 East 73rd Street, New York, NY, 10021, USA.
  • Cowen E; Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, 530 East 73rd Street, New York, NY, 10021, USA.
  • Navarrete-Dechent C; Downstate Medical Center College of Medicine, Brooklyn, NY, USA.
  • Busam KJ; Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, 530 East 73rd Street, New York, NY, 10021, USA.
  • Rossi AM; Department of Dermatology, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
  • Lee EH; Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, 530 East 73rd Street, New York, NY, 10021, USA.
  • Nehal KS; Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, 530 East 73rd Street, New York, NY, 10021, USA.
Arch Dermatol Res ; 2020 Sep 04.
Artigo em Inglês | MEDLINE | ID: mdl-32886149
ABSTRACT
Squamous cell carcinoma in situ (SCCIS) of the nail unit is a complex malignancy; with little understanding of rate of upstaging or occult invasion in these patients. We sought to evaluate the rate of upstaging in nail unit SCCIS after Mohs micrographic surgery (MMS). Retrospective review of 346 patients who referred for and underwent MMS for biopsy proven SCCIS on the hands and feet between January 1, 2000 and December 30, 2019. Only cases in the nail unit were included. Clinical, surgical details, histopathological features, HPV status, and rate of upstaging were recorded. Thirty-one cases met the inclusion criteria and were analyzed. Twenty-four patients were males (77.4%). The mean age was 55 years (SD 17.26, range 27-84). The mean clinical size was 9.9 mm; 19 cases tested for HPV, 15/19 were positive (78.9%), and 8/19 (42.1%) were associated with high-risk HPV. Three patients (9.7%) were upstaged to invasive on either MMS margins or tumor debulking. Limitations included a relatively small sample size and retrospective in nature. The rate of upstaging of SCCIS in the nail unit is not frequent, and when upstaging occurred it was focal, superficial, and with no PNI or bone invasion.
Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Idioma: Inglês Ano de publicação: 2020 Tipo de documento: Artigo País de afiliação: Estados Unidos

Similares

MEDLINE

...
LILACS

LIS

Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Idioma: Inglês Ano de publicação: 2020 Tipo de documento: Artigo País de afiliação: Estados Unidos
...