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BioAider: An efficient tool for viral genome analysis and its application in tracing SARS-CoV-2 transmission.
Zhou, Zhi-Jian; Qiu, Ye; Pu, Ying; Huang, Xun; Ge, Xing-Yi.
Afiliação
  • Zhou ZJ; Hunan Provincial Key Laboratory of Medical Virology, Institute of Pathogen Biology and Immunology, College of Biology, Hunan University, Changsha, China.
  • Qiu Y; Hunan Provincial Key Laboratory of Medical Virology, Institute of Pathogen Biology and Immunology, College of Biology, Hunan University, Changsha, China.
  • Pu Y; Department of Hospital Infection Control Center, Xiangya Hospital of Central South University, Changsha, China.
  • Huang X; Department of Endocrine Subspecialty of Gerontology, Xiangya Hospital of Central South University, Changsha, China.
  • Ge XY; Department of Hospital Infection Control Center, Xiangya Hospital of Central South University, Changsha, China.
Sustain Cities Soc ; 63: 102466, 2020 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-32904401
ABSTRACT
The novel human coronavirus (SARS-CoV-2) causes the coronavirus disease 2019 (COVID-19) pandemic worldwide. Control of COVID-19 pandemic is vital for public health and is the prerequisite to maintain social stability. However, the origin and transmission route of SARS-CoV-2 is unclear, bringing huge difficult to virus control. Monitoring viral variation and screening functional mutation sites are crucial for prevention and control of infectious diseases. In this study, we developed a user-friendly software, named BioAider, for quick sequence annotation and mutation analysis on large-scale genome-sequencing data. Herein, we detected 14 substitution hotspots within 3,240 SARS-CoV-2 genome sequences, including 3 groups of potentially linked substitution. NSP13-Y541C was crucial substitution which might affect the unwinding activity of the viral helicase. In particular, we discovered a SR-rich region of SARS-CoV-2 distinct from SARS-CoV, indicating more complex replication mechanism and unique N-M interaction of SARS-CoV-2. Interestingly, the quantity of SSRX repeat fragments in SARS-CoV-2 provided further evidence of its animal origin. Overall, we developed an efficient tool for rapid identification of viral genome mutations which could facilitate viral genomic studies. Using this tool, we have found critical clues for the transmission route of SARS-CoV-2 which would provide theoretical support for the epidemic control of pathogenic coronaviruses.
Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Idioma: Inglês Revista: Sustain Cities Soc Ano de publicação: 2020 Tipo de documento: Artigo País de afiliação: China

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Idioma: Inglês Revista: Sustain Cities Soc Ano de publicação: 2020 Tipo de documento: Artigo País de afiliação: China