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Clinicopathological and prognostic significance of PD-L1 expression in colorectal cancer: a meta-analysis.
Wang, Shuxia; Yuan, Bo; Wang, Yun; Li, Mingyang; Liu, Xibo; Cao, Jing; Li, Changtian; Hu, Jihong.
Afiliação
  • Wang S; Public Health School, Gansu University of Chinese Medicine, Lanzhou, 730000, China.
  • Yuan B; Basic Medical School, Gansu University of Chinese Medicine, Lanzhou, 730000, China.
  • Wang Y; Public Health School, Gansu University of Chinese Medicine, Lanzhou, 730000, China.
  • Li M; Public Health School, Gansu University of Chinese Medicine, Lanzhou, 730000, China.
  • Liu X; Public Health School, Gansu University of Chinese Medicine, Lanzhou, 730000, China.
  • Cao J; Public Health School, Gansu University of Chinese Medicine, Lanzhou, 730000, China.
  • Li C; Basic Medical School, Gansu University of Chinese Medicine, Lanzhou, 730000, China.
  • Hu J; Center of Research and Experiment, Gansu University of Chinese Medicine, Lanzhou, 730000, China. hujihonghappy@163.com.
Int J Colorectal Dis ; 2020 Sep 10.
Artigo em Inglês | MEDLINE | ID: mdl-32910207
ABSTRACT

PURPOSE:

To systematically evaluate the correlation between PD-L1 expression and clinicopathological features and prognosis of colorectal cancer (CRC).

METHODS:

Seven databases (PubMed, Cochrane Library, EMBASE, Web of Science, CBM, Wanfang, and CNKI) were searched through May 2020. Risk of bias and quality of evidence were assessed by using the Newcastle-Ottawa scale (NOS), and meta-analysis was carried out by using the Review Manager 5.3 software on the studies with the quality evaluation scores ≥ 6. Meta-regression analysis was used to determine the independent role of PD-L1 expression on CRC prognosis after adjusting clinicopathological features and treatment methods.

RESULTS:

A total of 8823 CRC patients in 32 eligible studies. PD-L1 expression was correlated with lymphatic metastasis (yes/no; OR = 1.24, 95% CI (1.11, 1.38)), diameter of tumor (≥ 5 cm/< 5 cm; OR = 1.34, 95% CI (1.06, 1.70)), differentiation (high-middle/low; OR = 0.68, 95% CI (0.53, 0.87)), and vascular invasion (yes/no; OR = 0.80, 95% CI (0.69, 0.92)). PD-L1 expression shortened the overall survival (hazard ratio (HR) = 1.93, 95% CI (1.66, 2.25)), disease-free survival (HR = 1.76, 95% CI (1.50, 2.07)), and progression-free survival (HR = 1.93, 95% CI (1.55, 2.41)). Meta-regression showed that PD-L1 expression played a significant role on poor CRC OS (HR = 1.95, 95% CI (1.92, 3.98)) and disease-free survival (HR = 2.14, 95% CI (0.73, 4.52)).

CONCLUSION:

PD-L1 expression independently predicted a poor prognosis of CRC.
Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Tipo de estudo: Estudo prognóstico / Revisão sistemática Idioma: Inglês Assunto da revista: Gastroenterologia Ano de publicação: 2020 Tipo de documento: Artigo País de afiliação: China

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Tipo de estudo: Estudo prognóstico / Revisão sistemática Idioma: Inglês Assunto da revista: Gastroenterologia Ano de publicação: 2020 Tipo de documento: Artigo País de afiliação: China
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