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Prolonged ursodeoxycholic acid administration reduces acute ischaemia-induced arrhythmias in adult rat hearts.
Ferraro, Elisa; Pozhidaeva, Lidia; Pitcher, David S; Mansfield, Catherine; Koh, Jia Han Benjamin; Williamson, Catherine; Aslanidi, Oleg; Gorelik, Julia; Ng, Fu Siong.
Afiliação
  • Ferraro E; National Heart and Lung Institute, Imperial College London, London, UK.
  • Pozhidaeva L; School of Biomedical Engineering and Imaging Science, King's College London, London, UK.
  • Pitcher DS; National Heart and Lung Institute, Imperial College London, London, UK.
  • Mansfield C; National Heart and Lung Institute, Imperial College London, London, UK.
  • Koh JHB; School of Biomedical Engineering and Imaging Science, King's College London, London, UK.
  • Williamson C; Department of Women and Children's Health, King's College London, London, UK.
  • Aslanidi O; School of Biomedical Engineering and Imaging Science, King's College London, London, UK.
  • Gorelik J; National Heart and Lung Institute, Imperial College London, London, UK. j.gorelik@ic.ac.uk.
  • Ng FS; National Heart and Lung Institute, Imperial College London, London, UK. f.ng@imperial.ac.uk.
Sci Rep ; 10(1): 15284, 2020 09 17.
Artigo em Inglês | MEDLINE | ID: mdl-32943714
ABSTRACT
Acute myocardial ischaemia and reperfusion (I-R) are major causes of ventricular arrhythmias in patients with a history of coronary artery disease. Ursodeoxycholic acid (UDCA) has previously been shown to be antiarrhythmic in fetal hearts. This study was performed to investigate if UDCA protects against ischaemia-induced and reperfusion-induced arrhythmias in the adult myocardium, and compares the effect of acute (perfusion only) versus prolonged (2 weeks pre-treatment plus perfusion) UDCA administration. Langendorff-perfused adult Sprague-Dawley rat hearts were subjected to acute regional ischaemia by ligation of the left anterior descending artery (10 min), followed by reperfusion (2 min), and arrhythmia incidence quantified. Prolonged UDCA administration reduced the incidence of acute ischaemia-induced arrhythmias (p = 0.028), with a reduction in number of ventricular ectopic beats during the ischaemic phase compared with acute treatment (10 ± 3 vs 58 ± 15, p = 0.036). No antiarrhythmic effect was observed in the acute UDCA administration group. Neither acute nor prolonged UDCA treatment altered the incidence of reperfusion arrhythmias. The antiarrhythmic effect of UDCA may be partially mediated by an increase in cardiac wavelength, due to the attenuation of conduction velocity slowing (p = 0.03), and the preservation of Connexin43 phosphorylation during acute ischaemia (p = 0.0027). The potential antiarrhythmic effects of prolonged UDCA administration merit further investigation.
Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Idioma: Inglês Revista: Sci Rep Ano de publicação: 2020 Tipo de documento: Artigo País de afiliação: Reino Unido

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Idioma: Inglês Revista: Sci Rep Ano de publicação: 2020 Tipo de documento: Artigo País de afiliação: Reino Unido