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Comparison of COVID-19 disease between young and elderly patients: Hidden viral shedding of COVID-19.
Mori, Hitoshi; Obinata, Hirofumi; Murakami, Wakana; Tatsuya, Kodama; Sasaki, Hisashi; Miyake, Yu; Taniguchi, Yasuaki; Ota, Shinichiro; Yamaga, Mitsuki; Suyama, Yohsuke; Tamura, Kaku.
Afiliação
  • Mori H; Department of Internal Medicine, Self Defense Forces Central Hospital, Japan. Electronic address: zin_ndmc@yahoo.co.jp.
  • Obinata H; Department of Internal Medicine, Self Defense Forces Central Hospital, Japan.
  • Murakami W; Department of Radiology, Self Defense Forces Hospital Yokosuka, Japan.
  • Tatsuya K; Department of Internal Medicine, Self Defense Forces Central Hospital, Japan.
  • Sasaki H; Department of Internal Medicine, Self Defense Forces Central Hospital, Japan.
  • Miyake Y; Department of Internal Medicine, Self Defense Forces Central Hospital, Japan.
  • Taniguchi Y; Department of Internal Medicine, Self Defense Forces Central Hospital, Japan.
  • Ota S; Department of Internal Medicine, Self Defense Forces Central Hospital, Japan.
  • Yamaga M; Department of Internal Medicine, Self Defense Forces Central Hospital, Japan.
  • Suyama Y; Department of Radiology, National Defense Medical College, Japan.
  • Tamura K; Department of Internal Medicine, Self Defense Forces Central Hospital, Japan.
J Infect Chemother ; 27(1): 70-75, 2021 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-32950393
ABSTRACT

OBJECTIVES:

The symptoms of Coronavirus disease 2019 (COVID-19) vary among patients. The aim of this study was to investigate the clinical manifestation and disease duration in young versus elderly patients.

METHODS:

We retrospectively analyzed 187 patients (87 elderly and 100 young patients) with confirmed COVID-19. The clinical characteristics and chest computed tomography (CT) extent as defined by a score were compared between the two groups.

RESULTS:

The numbers of asymptomatic cases and severe cases were significantly higher in the elderly group (elderly group vs. young group; asymptomatic cases, 31 [35.6%] vs. 10 [10%], p < 0.0001; severe cases, 25 [28.7%] vs. 8 [8.0%], p = 0.0002). The proportion of asymptomatic patients and severe patients increased across the 10-year age groups. There was no significant difference in the total CT score and number of abnormal cases. A significant positive correlation between the disease duration and patient age was observed in asymptomatic patients (ρ = 0.4570, 95% CI 0.1198-0.6491, p = 0.0034).

CONCLUSIONS:

Although the extent of lung involvement did not have a significant difference between the young and elderly patients, elderly patients were more likely to have severe clinical manifestations. Elderly patients were also more likely to be asymptomatic and a source of COVID-19 viral shedding.
Assuntos
Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Pneumonia Viral / Eliminação de Partículas Virais / Infecções por Coronavirus / Infecções Assintomáticas Tipo de estudo: Estudo observacional / Fatores de risco Limite: Adulto / Idoso / Feminino / Humanos / Masculino / Meia-Idade Idioma: Inglês Revista: J Infect Chemother Assunto da revista: Microbiologia / Terapia por Medicamentos Ano de publicação: 2021 Tipo de documento: Artigo

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Pneumonia Viral / Eliminação de Partículas Virais / Infecções por Coronavirus / Infecções Assintomáticas Tipo de estudo: Estudo observacional / Fatores de risco Limite: Adulto / Idoso / Feminino / Humanos / Masculino / Meia-Idade Idioma: Inglês Revista: J Infect Chemother Assunto da revista: Microbiologia / Terapia por Medicamentos Ano de publicação: 2021 Tipo de documento: Artigo
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