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Predicting the effect of statins on cancer risk using genetic variants from a Mendelian randomization study in the UK Biobank.
Carter, Paul; Vithayathil, Mathew; Kar, Siddhartha; Potluri, Rahul; Mason, Amy M; Larsson, Susanna C; Burgess, Stephen.
Afiliação
  • Carter P; Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
  • Vithayathil M; MRC Cancer Unit, University of Cambridge, Cambridge, United Kingdom.
  • Kar S; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom.
  • Potluri R; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.
  • Mason AM; ACALM Study Unit, Aston Medical School, Birmingham, United Kingdom.
  • Larsson SC; Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
  • Burgess S; Unit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Elife ; 92020 10 13.
Artigo em Inglês | MEDLINE | ID: mdl-33046214
ABSTRACT
Laboratory studies have suggested oncogenic roles of lipids, as well as anticarcinogenic effects of statins. Here we assess the potential effect of statin therapy on cancer risk using evidence from human genetics. We obtained associations of lipid-related genetic variants with the risk of overall and 22 site-specific cancers for 367,703 individuals in the UK Biobank. In total, 75,037 individuals had a cancer event. Variants in the HMGCR gene region, which represent proxies for statin treatment, were associated with overall cancer risk (odds ratio [OR] per one standard deviation decrease in low-density lipoprotein [LDL] cholesterol 0.76, 95% confidence interval [CI] 0.65-0.88, p=0.0003) but variants in gene regions representing alternative lipid-lowering treatment targets (PCSK9, LDLR, NPC1L1, APOC3, LPL) were not. Genetically predicted LDL-cholesterol was not associated with overall cancer risk (OR per standard deviation increase 1.01, 95% CI 0.98-1.05, p=0.50). Our results predict that statins reduce cancer risk but other lipid-lowering treatments do not. This suggests that statins reduce cancer risk through a cholesterol independent pathway.
Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Tipo de estudo: Estudo de etiologia / Estudo prognóstico / Fatores de risco Idioma: Inglês Ano de publicação: 2020 Tipo de documento: Artigo País de afiliação: Reino Unido

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Tipo de estudo: Estudo de etiologia / Estudo prognóstico / Fatores de risco Idioma: Inglês Ano de publicação: 2020 Tipo de documento: Artigo País de afiliação: Reino Unido
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