Targeting BCL10 by small peptides for the treatment of B cell lymphoma.

Bao, Wei; Sun, Chenxia; Sun, Xiaochen; He, Miaoxia; Yu, Haolan; Yan, Wenfen; Wen, Fuping; Zhang, Liang; Yang, Chenghua

Bao, Wei; Sun, Chenxia; Sun, Xiaochen; He, Miaoxia; Yu, Haolan; Yan, Wenfen; Wen, Fuping; Zhang, Liang; Yang, Chenghua.

Afiliação

Bao W; Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai, China, 200433.
Sun C; CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China, 200031.
Sun X; Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai, China, 200433.
He M; CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China, 200031.
Yu H; Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai, China, 200433.
Yan W; CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China, 200031.
Wen F; Department of Pathology, Changhai Hospital, Second Military Medical University, Shanghai, China, 200433.
Zhang L; Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai, China, 200433.
Yang C; CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China, 200031.

Theranostics ; 10(25): 11622-11636, 2020.

Article em En | MEDLINE | ID: mdl-33052237

Assuntos

Antineoplásicos/farmacologia; Proteína 10 de Linfoma CCL de Células B/antagonistas & inibidores; Linfoma Difuso de Grandes Células B/tratamento farmacológico; Peptídeos/farmacologia; Animais; Antineoplásicos/uso terapêutico; Apoptose/efeitos dos fármacos; Proteína 10 de Linfoma CCL de Células B/metabolismo; Proteína 10 de Linfoma CCL de Células B/ultraestrutura; Proteínas Adaptadoras de Sinalização CARD/metabolismo; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; Ensaios de Seleção de Medicamentos Antitumorais; Feminino; Guanilato Ciclase/metabolismo; Humanos; Linfoma Difuso de Grandes Células B/patologia; Camundongos; Microscopia Eletrônica; Proteína de Translocação 1 do Linfoma de Tecido Linfoide Associado à Mucosa/metabolismo; NF-kappa B/metabolismo; Peptídeos/uso terapêutico; Multimerização Proteica/efeitos dos fármacos; Estabilidade Proteica/efeitos dos fármacos; Transdução de Sinais/efeitos dos fármacos; Ensaios Antitumorais Modelo de Xenoenxerto

Palavras-chave

Bcl10; Bcl10 peptide inhibitors (BPIs); CARMA1-BCL10 supramolecular organizing centre (CB-SMOC); NF-κB; diffuse large B-cell lymphoma (DLBCL)

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos / Linfoma Difuso de Grandes Células B / Proteína 10 de Linfoma CCL de Células B / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Theranostics Ano de publicação: 2020 Tipo de documento: Article País de publicação: Austrália

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google