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Biocompatibility, Biomineralization, and Maturation of Collagen by RTR®, Bioglass and DM Bone® Materials.
Benetti, Francine; Bueno, Carlos Roberto Emerenciano; Reis-Prado, Alexandre Henrique Dos; Souza, Marina Trevelin; Goto, Juliana; Camargo, Jose Maurício Paradella de; Duarte, Marco Antônio Húngaro; Dezan-Júnior, Elói; Zanotto, Edgar Dutra; Cintra, Luciano Tavares Angelo.
Afiliação
  • Benetti F; Department of Restorative Dentistry, School of Dentistry, UFMG - Universidade Federal de Minas Gerais, , Belo Horizonte, MG, Brazil.
  • Bueno CRE; Department of Endodontics, School of Dentistry, UNESP - Universidade Estadual Paulista, Araçatuba, SP, Brazil.
  • Reis-Prado AHD; Department of Endodontics, School of Dentistry, UNESP - Universidade Estadual Paulista, Araçatuba, SP, Brazil.
  • Souza MT; Department of Restorative Dentistry, School of Dentistry, UFMG - Universidade Federal de Minas Gerais, , Belo Horizonte, MG, Brazil.
  • Goto J; Department of Materials Engineering, Vitreous Materials Laboratory (LaMaV) UFSCar - Universidade Federal de São Carlos, SP, Brazil.
  • Camargo JMP; Department of Endodontics, School of Dentistry, UNESP - Universidade Estadual Paulista, Araçatuba, SP, Brazil.
  • Duarte MAH; Department of Endodontics, School of Dentistry, UNESP - Universidade Estadual Paulista, Araçatuba, SP, Brazil.
  • Dezan-Júnior E; Department of Dentistry, Endodontics and Dental Materials, School of Dentistry, USP - Universidade de São Paulo, Bauru, SP, Brazil.
  • Zanotto ED; Department of Endodontics, School of Dentistry, UNESP - Universidade Estadual Paulista, Araçatuba, SP, Brazil.
  • Cintra LTA; Department of Materials Engineering, Vitreous Materials Laboratory (LaMaV) UFSCar - Universidade Federal de São Carlos, SP, Brazil.
Braz Dent J ; 31(5): 477-484, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33146330
ABSTRACT
This study evaluated the biocompatibility, biomineralization, and collagen fiber maturation induced by Resorbable Tissue Replacement (RTR®; ß-tricalcium phosphate [TCP]), Bioglass (BIOG; bioactive glass), and DM Bone® (DMB; hydroxyapatite and ß-TCP) in vivo. Sixty-four polyethylene tubes with or without (control group; CG) materials (n=8/group/period) were randomly implanted in the subcutaneous tissue of 16 male Wistar rats (four per rat), weighting 250 to 280 g. The rats were killed after 7 and 30 days (n=8), and the specimens were removed for analysis of inflammation using hematoxylin-eosin; biomineralization assay using von Kossa (VK) staining and polarized light (PL); and collagen fiber maturation using picrosirius red (PSR). Nonparametric data were statistically analyzed by Kruskal-Wallis and Dunn tests, and parametric data by one-way ANOVA test (p<0.05). At 7 days, all groups induced moderate inflammation (p>0.05). At 30 days, there was mild inflammation in the BIOG and CG, and moderate inflammation in the RTR and DMB groups, with a significant difference between the CG and RTR (p<0.05). The fibrous capsule was thick at 7 days and predominantly thin at 30 days in all groups. All materials exhibited structures that stained positively for VK and PL. Immature collagen fibers were predominant at 7 and 30 days in all groups (p>0.05), although DMB exhibited more mature fibers than BIOG at 30 days (p<0.05). RTR, BIOG, and DMB were biocompatible, inducing inflammation that reduced over time and biomineralization in the subcutaneous tissue of rats. DMB exhibited more mature collagen fibers than BIOG over a longer period.
Assuntos
Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Materiais Restauradores do Canal Radicular / Biomineralização Tipo de estudo: Estudo observacional Limite: Animais Idioma: Inglês Revista: Braz Dent J Assunto da revista: Odontologia Ano de publicação: 2020 Tipo de documento: Artigo País de afiliação: Brasil

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Materiais Restauradores do Canal Radicular / Biomineralização Tipo de estudo: Estudo observacional Limite: Animais Idioma: Inglês Revista: Braz Dent J Assunto da revista: Odontologia Ano de publicação: 2020 Tipo de documento: Artigo País de afiliação: Brasil