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Prediction of hospitalizations in systemic lupus erythematosus using the Systemic Lupus International Collaborating Clinics Frailty Index (SLICC-FI).
Legge, Alexandra; Kirkland, Susan; Rockwood, Kenneth; Andreou, Pantelis; Bae, Sang-Cheol; Gordon, Caroline; Romero-Diaz, Juanita; Sanchez-Guerrero, Jorge; Wallace, Daniel J; Bernatsky, Sasha; Clarke, Ann E; Merrill, Joan T; Ginzler, Ellen M; Fortin, Paul R; Gladman, Dafna D; Urowitz, Murray B; Bruce, Ian N; Isenberg, David A; Rahman, Anisur; Alarcón, Graciela S; Petri, Michelle; Khamashta, Munther A; Dooley, M A; Ramsey-Goldman, Rosalind; Manzi, Susan; Zoma, Asad A; Aranow, Cynthia; Mackay, Meggan; Ruiz-Irastorza, Guillermo; Lim, S Sam; Inanc, Murat; van Vollenhoven, Ronald F; Jonsen, Andreas; Nived, Ola; Ramos-Casals, Manuel; Kamen, Diane L; Kalunian, Kenneth C; Jacobsen, Soren; Peschken, Christine A; Askanase, Anca; Hanly, John G.
Afiliação
  • Legge A; Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada.
  • Kirkland S; Department of Community Health & Epidemiology, Dalhousie University, Halifax, Nova Scotia, Canada.
  • Rockwood K; Division of Geriatric Medicine, Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada.
  • Andreou P; Department of Community Health & Epidemiology, Dalhousie University, Halifax, Nova Scotia, Canada.
  • Bae SC; Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea.
  • Gordon C; Rheumatology Research Group, Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
  • Romero-Diaz J; Instituto Nacional de Ciencias Médicas y Nutrición, Mexico City, Mexico.
  • Sanchez-Guerrero J; Instituto Nacional de Ciencias Médicas y Nutrición, Mexico City, Mexico.
  • Wallace DJ; Cedars-Sinai/David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
  • Bernatsky S; Divisions of Rheumatology and Clinical Epidemiology, Department of Medicine, McGill University, Montreal, Quebec, Canada.
  • Clarke AE; Division of Rheumatology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
  • Merrill JT; Department of Clinical Pharmacology, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.
  • Ginzler EM; Department of Medicine, SUNY Downstate Medical Center, Brooklyn, NY, USA.
  • Fortin PR; Division of Rheumatology, CHU de Québec - Université Laval, Quebec City, Canada.
  • Gladman DD; Center for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital and University of Toronto, ON, Canada, Oakland.
  • Urowitz MB; Center for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital and University of Toronto, ON, Canada, Oakland.
  • Bruce IN; Arthritis Research UK Epidemiology Unit, Faculty of Biology Medicine and Health, Manchester Academic Health Sciences Center, The University of Manchester, and NIHR Manchester Musculoskeletal Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Ce
  • Isenberg DA; Center for Rheumatology, Department of Medicine, University College London, UK, London.
  • Rahman A; Center for Rheumatology, Department of Medicine, University College London, UK, London.
  • Alarcón GS; Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
  • Petri M; Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Khamashta MA; Lupus Research Unit, The Rayne Institute, St Thomas' Hospital, King's College London School of Medicine, London, UK.
  • Dooley MA; Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC, USA, Chapel Hill.
  • Ramsey-Goldman R; Northwestern University and Feinberg School of Medicine, Chicago, IL, USA.
  • Manzi S; Lupus Center of Excellence, Allegheny Health Network, Pittsburgh, PA, USA.
  • Zoma AA; Lanarkshire Center for Rheumatology, Hairmyres Hospital, East Kilbride, Scotland, UK.
  • Aranow C; Feinstein Institute for Medical Research, Manhasset, NY, USA.
  • Mackay M; Feinstein Institute for Medical Research, Manhasset, NY, USA.
  • Ruiz-Irastorza G; Autoimmune Diseases Research Unit, Department of Internal Medicine, BioCruces Bizkaia Health Research Institute, Hospital Universitario Cruces, University of the Basque Country, Barakaldo, Spain.
  • Lim SS; Emory University School of Medicine, Division of Rheumatology, Atlanta, Georgia, USA.
  • Inanc M; Division of Rheumatology, Department of Internal Medicine, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey.
  • van Vollenhoven RF; Unit for clinical therapy research (ClinTRID), Karolinska Institute, Stockholm, Sweden.
  • Jonsen A; Department of Clinical Sciences Lund, Rheumatology, Lund University, Lund, Sweden.
  • Nived O; Department of Clinical Sciences Lund, Rheumatology, Lund University, Lund, Sweden.
  • Ramos-Casals M; Josep Font Autoimmune Diseases Laboratory, IDIBAPS, Department of Autoimmune Diseases, Hospital Clínic, Barcelona, Spain.
  • Kamen DL; Medical University of South Carolina, Charleston, South Carolina, USA.
  • Kalunian KC; UCSD School of Medicine, La Jolla, CA, USA, Oakland.
  • Jacobsen S; Copenhagen Lupus and Vasculitis Clinic, 4242, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
  • Peschken CA; University of Manitoba, Winnipeg, Manitoba, Canada.
  • Askanase A; Hospital for Joint Diseases, NYU, Seligman Center for Advanced Therapeutics, New York, NY, USA.
  • Hanly JG; Division of Rheumatology, Department of Medicine and Department of Pathology, Queen Elizabeth II Health Sciences Center and Dalhousie University, Halifax, Nova Scotia, Canada.
Artigo em Inglês | MEDLINE | ID: mdl-33152181
ABSTRACT

OBJECTIVE:

The Systemic Lupus International Collaborating Clinics (SLICC) frailty index (FI) predicts mortality and damage accrual in SLE, but its association with hospitalizations has not been described. We estimated the association of baseline SLICC-FI values with future hospitalizations in the SLICC inception cohort.

METHODS:

Baseline SLICC-FI scores were calculated. The number and duration of inpatient hospitalizations during follow-up were recorded. Negative binomial regression was used to estimate the association between baseline SLICC-FI values and the rate of hospitalizations per patient-year of follow-up. Linear regression was used to estimate the association of baseline SLICC-FI scores with the proportion of follow-up time spent in hospital. Multivariable models were adjusted for relevant baseline characteristics.

RESULTS:

The 1549 SLE patients eligible for this analysis were mostly female (88.7%) with mean (SD) age 35.7 (13.3) years and median (IQR) disease duration 1.2 (0.9-1.5) years at baseline. Mean (SD) baseline SLICC-FI was 0.17 (0.08). During mean (SD) follow-up of 7.2 (3.7) years, 614 patients (39.6%) experienced 1570 hospitalizations. Higher baseline SLICC-FI values (per 0.05 increment) were associated with more frequent hospitalizations during follow-up (Incidence Rate Ratio 1.21; 95%CI 1.13-1.30), adjusting for baseline age, sex, corticosteroid use, immunosuppressive use, ethnicity/location, SLE disease activity index 2000 (SLEDAI-2K), SLICC/ACR damage index (SDI), and disease duration. Among patients with ≥1 hospitalization, higher baseline SLICC-FI values predicted a greater proportion of follow-up time spent hospitalized (Relative Rate 1.09; 95%CI 1.02-1.16).

CONCLUSION:

The SLICC-FI predicts future hospitalizations among incident SLE patients, further supporting the SLICC-FI as a valid health measure in SLE.
Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Tipo de estudo: Estudo prognóstico / Fatores de risco Idioma: Inglês Assunto da revista: Reumatologia Ano de publicação: 2020 Tipo de documento: Artigo País de afiliação: Canadá

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Tipo de estudo: Estudo prognóstico / Fatores de risco Idioma: Inglês Assunto da revista: Reumatologia Ano de publicação: 2020 Tipo de documento: Artigo País de afiliação: Canadá