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Overall and abdominal obesity in relation to venous thromboembolism.
Yuan, Shuai; Bruzelius, Maria; Xiong, Ying; Håkansson, Niclas; Åkesson, Agneta; Larsson, Susanna C.
Afiliação
  • Yuan S; Unit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
  • Bruzelius M; Coagulation Unit, Department of Hematology, Karolinska University Hospital, Stockholm, Sweden.
  • Xiong Y; Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
  • Håkansson N; Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden.
  • Åkesson A; Unit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
  • Larsson SC; Unit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
J Thromb Haemost ; 2020 Nov 12.
Artigo em Inglês | MEDLINE | ID: mdl-33179380
ABSTRACT

BACKGROUND:

Abdominal obesity has been shown to be a superior measure over overall obesity for detecting cardiovascular risk.

OBJECTIVE:

We conducted this study to compare the effects of overall and central obesity on VTE and to calculate population attributable fraction for obesity for VTE.

METHODS:

Body mass index (BMI) and waist circumference (WC) was used to represent overall and abdominal obesity, respectively. In the cohort study, we included 74,317 Swedish adults with anthropometric measures in 1997 and of whom 4332 were diagnosed with VTE until the end of 2017. A Mendelian randomization study was conducted to investigate causal associations of BMI, WC, and WC adjusted for BMI with VTE using data from FinnGen and UK Biobank study. Population attributable fraction was calculated for overall and abdominal obesity for VTE.

RESULTS:

In the cohort study, there were dose-response associations of BMI and WC with VTE. The association between BMI and VTE was attenuated largely after adjusting for WC. Among individuals with normal BMI, participants with substantially increased WC had 53% higher (HR 1.53; 95% CI, 1.28, 1.81) risk of VTE compared with those with normal WC. The causality of the association of WC adjusted for BMI with VTE was confirmed in MR analysis. The estimated population-attributable risk due to elevated BMI and WC were 12.4% (8.4%, 16.5%) and 23.7% (18.1%, 29.4%), respectively.

CONCLUSIONS:

WC might be a preferable indictor linking obesity to VTE. A large proportion of VTE cases can be prevented if the population maintained a healthy BMI and WC.
Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Tipo de estudo: Estudo observacional / Fatores de risco Idioma: Inglês Assunto da revista: Hematologia Ano de publicação: 2020 Tipo de documento: Artigo País de afiliação: Suécia

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Tipo de estudo: Estudo observacional / Fatores de risco Idioma: Inglês Assunto da revista: Hematologia Ano de publicação: 2020 Tipo de documento: Artigo País de afiliação: Suécia
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