Your browser doesn't support javascript.
loading
Association between the A46G polymorphism (rs1042713) in the ß2-adrenergic receptor gene and essential hypertension susceptibility in the Chinese population: A PRISMA-compliant meta-analysis.
Yan, Liyuan; Wang, Haipeng; Liu, Pengfei; Wang, Minghan; Chen, Jingjing; Zhao, Xin.
Afiliação
  • Yan L; Department of Cardiology, the First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Medicine (Baltimore) ; 99(46): e23164, 2020 Nov 13.
Artigo em Inglês | MEDLINE | ID: mdl-33181690
ABSTRACT

BACKGROUND:

Recently, many studies have been conducted to investigate the relationship between the A46G polymorphism in the ß2-adrenergic receptor (ADRB2) gene and essential hypertension risk in the Chinese population. However, the results of previous studies were conflicting.

OBJECTIVES:

The present study aimed to investigate the association between the ADRB2 A46G polymorphism and the risk of essential hypertension in the Chinese population.

METHODS:

We performed a systematic search of possible relevant studies on PubMed, Embase, Ovid, Web of Science, China National Knowledge Infrastructure, Wanfang, and China Biology Medicine disc databases up to January 3, 2020. Two authors independently extracted information from included articles and assessed the quality of each study by the use of the Newcastle-Ottawa Scale. According to the extent of interstudy heterogeneity, either a random-effect model or a fixed-effect model was used to calculate the combined odds ratio (OR) and 95% confidence interval (CI).

RESULTS:

Finally, 16 studies containing 3390 cases and 2528 controls were included in our meta-analysis. Significant associations were found between the ADRB2 A46G polymorphism and essential hypertension risk in the Chinese population under four genetic models allele genetic model (OR 1.14, 95% CI 1.06-1.23, P = .001, Pheterogeneity = .09), homozygote genetic model (OR 1.29, 95% CI 1.11-1.51, P = .001, Pheterogeneity = .25), dominant genetic model (OR 1.17, 95% CI 1.05-1.32, P = .005, Pheterogeneity = .04), and recessive genetic model (OR 1.21, 95% CI 1.05-1.38, P = .007, Pheterogeneity = .72).

CONCLUSION:

The ADRB2 A46G polymorphism may increase the risk of essential hypertension in the Chinese population.
Assuntos
Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Receptores Adrenérgicos beta 2 / Hipertensão Essencial Tipo de estudo: Estudo observacional / Fatores de risco / Revisão sistemática Limite: Humanos Idioma: Inglês Revista: Medicine (Baltimore) Ano de publicação: 2020 Tipo de documento: Artigo País de afiliação: China

Similares

MEDLINE

...
LILACS

LIS

Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Receptores Adrenérgicos beta 2 / Hipertensão Essencial Tipo de estudo: Estudo observacional / Fatores de risco / Revisão sistemática Limite: Humanos Idioma: Inglês Revista: Medicine (Baltimore) Ano de publicação: 2020 Tipo de documento: Artigo País de afiliação: China
...