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Clinical biochemical parameters associated with the exposure to multiple environmental metals in residents from Kabwe, Zambia.
Nakata, Hokuto; Nakayama, Shouta M M; Yabe, John; Muzandu, Kaampwe; Toyomaki, Haruya; Yohannes, Yared Beyene; Kataba, Andrew; Zyambo, Golden; Ikenaka, Yoshinori; Choongo, Kennedy; Ishizuka, Mayumi.
Afiliação
  • Nakata H; Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Kita 18 Nishi 9, Kita-ku, Sapporo, 060-0818, Japan.
  • Nakayama SMM; Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Kita 18 Nishi 9, Kita-ku, Sapporo, 060-0818, Japan.
  • Yabe J; The University of Zambia, School of Veterinary Medicine, P.O. Box 32379, Lusaka, Zambia.
  • Muzandu K; The University of Zambia, School of Veterinary Medicine, P.O. Box 32379, Lusaka, Zambia.
  • Toyomaki H; Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Kita 18 Nishi 9, Kita-ku, Sapporo, 060-0818, Japan.
  • Yohannes YB; Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Kita 18 Nishi 9, Kita-ku, Sapporo, 060-0818, Japan; Department of Chemistry, College of Natural and Computational Science, University of Gondar, Ethiopia.
  • Kataba A; Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Kita 18 Nishi 9, Kita-ku, Sapporo, 060-0818, Japan; The University of Zambia, School of Veterinary Medicine, P.O. Box 32379, Lusaka, Zambia.
  • Zyambo G; The University of Zambia, School of Veterinary Medicine, P.O. Box 32379, Lusaka, Zambia.
  • Ikenaka Y; Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Kita 18 Nishi 9, Kita-ku, Sapporo, 060-0818, Japan; Water Research Group, School of Environmental Sciences and Development, North-West University, South Africa.
  • Choongo K; The University of Zambia, School of Veterinary Medicine, P.O. Box 32379, Lusaka, Zambia; Fiji National University, College of Agriculture, Fisheries & Forestry, School of Animal and Veterinary Sciences, Koronivia Campus, Suva, Fiji.
  • Ishizuka M; Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Kita 18 Nishi 9, Kita-ku, Sapporo, 060-0818, Japan. Electronic address: ishizum@vetmed.hokudai.ac.jp.
Chemosphere ; 262: 127788, 2021 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-33182082
ABSTRACT
Lead (Pb) interferes with various bodily functions. Although high blood Pb (Pb-B) levels in residents from Kabwe, Zambia have been reported, the accumulation pattern of other metals remains unknown. The study was designed to determine the Pb-B, blood cadmium (Cd-B), and zinc (Zn-B) values of 504 representative samples from Kabwe, as well as the potential associated adverse health effects. The Pb-B level ranged from 0.79 to 154.75 µg/dL and generally increased in areas near the mine. A significant elevation of Cd-B was observed in two areas (0.37 ± 0.26 and 0.32 ± 0.30 µg/L) where the two highest mean Pb-B levels were recorded. By contrast, the Zn-B values did not differ greatly with respect to area. Some blood biochemical parameters relating to hepatic and renal functions were out of the normal range in approximately 20-50% of studied adult participants. The δ-aminolevulinic acid dehydratase (δ-ALAD) activity was significantly inhibited in the two areas contaminated by Pb and Cd. A significant negative relationship was observed between metal levels and clinical parameters, e.g., between Pb-B and δ-ALAD for all the age categories and between Cd-B and the estimated glomerular filtration rate for all the age categories except 0-4 years. The elevated Cd-B in areas near the mine relative to the other areas suggested the potential adverse health effects of Cd and/or the interaction of Pb and Cd. A significant association of metal levels with clinical parameters also indicated the effects of metal exposure on hematopoietic, hepatic, and renal systems.
Assuntos
Texto completo: Disponível Coleções: Bases de dados internacionais Contexto em Saúde: ODS3 - Saúde e Bem-Estar Tema em saúde: Meta 3.9: Reduzir o número de mortes por produtos químicos perigosos e contaminação do ar e água do solo Base de dados: MEDLINE Assunto principal: Exposição Ambiental / Poluentes Ambientais / Metais Tipo de estudo: Fatores de risco Limite: Adulto / Humanos / Jovem adulto País/Região como assunto: África Idioma: Inglês Revista: Chemosphere Ano de publicação: 2021 Tipo de documento: Artigo País de afiliação: Japão

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Texto completo: Disponível Coleções: Bases de dados internacionais Contexto em Saúde: ODS3 - Saúde e Bem-Estar Tema em saúde: Meta 3.9: Reduzir o número de mortes por produtos químicos perigosos e contaminação do ar e água do solo Base de dados: MEDLINE Assunto principal: Exposição Ambiental / Poluentes Ambientais / Metais Tipo de estudo: Fatores de risco Limite: Adulto / Humanos / Jovem adulto País/Região como assunto: África Idioma: Inglês Revista: Chemosphere Ano de publicação: 2021 Tipo de documento: Artigo País de afiliação: Japão