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Bridging Anxiety and Depression: A Network Approach in Anxious Adolescents.
Dobson, Eric T; Croarkin, Paul E; Schroeder, Heidi K; Varney, Sara T; Mossman, Sarah A; Cecil, Kim; Strawn, Jeffrey R.
Afiliação
  • Dobson ET; Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina. Electronic address: dobsoner@musc.edu.
  • Croarkin PE; Mayo Clinic Depression Center, Rochester, MN 55905.
  • Schroeder HK; Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati, College of Medicine, Cincinnati, OH 45219.
  • Varney ST; Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati, College of Medicine, Cincinnati, OH 45219.
  • Mossman SA; Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati, College of Medicine, Cincinnati, OH 45219.
  • Cecil K; Imaging Research Center, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45267.
  • Strawn JR; Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati, College of Medicine, Cincinnati, OH 45219.
J Affect Disord ; 280(Pt A): 305-314, 2020 Nov 11.
Artigo em Inglês | MEDLINE | ID: mdl-33221716
ABSTRACT

BACKGROUND:

The phenomenology and neurobiology of depressive symptoms in anxious youth is poorly understood.

METHODS:

Association networks of anxiety and depressive symptoms were developed in adolescents with generalized anxiety disorder (GAD; N=52, mean age 15.4±1.6 years) who had not yet developed major depressive disorder. Community analyses were used to create consensus clusters of depressive and anxiety symptoms and to identify "bridge" symptoms between the clusters. In a subset of this sample (n=39), correlations between cortical thickness and depressive symptom severity was examined.

RESULTS:

Ten symptoms clustered into an anxious community, 5 clustered into a depressive community and 5 bridged the two communities impaired schoolwork, excessive weeping, low self-esteem, disturbed appetite, and physical symptoms of depression. Patients with more depressive cluster burden had altered cortical thickness in prefrontal, inferior and medial parietal (e.g., precuneus, supramarginal) regions and had decreases in cortical thickness-age relationships in prefrontal, temporal and parietal cortices.

LIMITATIONS:

Data are cross-sectional and observational. Limited sample size precluded secondary analysis of comorbidities and demographics.

CONCLUSIONS:

In youth with GAD, a sub-set of symptoms not directly related to anxiety bridge anxiety and depression. Youth with greater depressive cluster burden had altered cortical thickness in cortical structures within the default mode and central executive networks. These alternations in cortical thickness may represent a distinct neurostructural fingerprint in anxious youth with early depressive symptoms. Finally, youth with GAD and high depressive symptoms had reduced age-cortical thickness correlations. The emergence of depressive symptoms in early GAD and cortical development may have bidirectional, neurobiological relationships.
Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Tipo de estudo: Pesquisa qualitativa Idioma: Inglês Revista: J Affect Disord Ano de publicação: 2020 Tipo de documento: Artigo

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Tipo de estudo: Pesquisa qualitativa Idioma: Inglês Revista: J Affect Disord Ano de publicação: 2020 Tipo de documento: Artigo
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