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Small Molecules Targeting HATs, HDACs, and BRDs in Cancer Therapy.
Wu, Donglu; Qiu, Ye; Jiao, Yunshuang; Qiu, Zhidong; Liu, Da.
Afiliação
  • Wu D; School of Clinical Medical, Changchun University of Chinese Medicine, Changchun, China.
  • Qiu Y; Key Laboratory of Effective Components of Traditional Chinese Medicine, Changchun, China.
  • Jiao Y; Key Laboratory of Effective Components of Traditional Chinese Medicine, Changchun, China.
  • Qiu Z; School of Pharmacy, Changchun University of Chinese Medicine, Changchun, China.
  • Liu D; School of Pharmacy, Changchun University of Chinese Medicine, Changchun, China.
Front Oncol ; 10: 560487, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33262941
ABSTRACT
Evidence for research over the past decade shows that epigenetic regulation mechanisms run through the development and prognosis of tumors. Therefore, small molecular compounds targeting epigenetic regulation have become a research hotspot in the development of cancer therapeutic drugs. According to the obvious abnormality of histone acetylation when tumors occur, it suggests that histone acetylation modification plays an important role in the process of tumorigenesis. Currently, as a new potential anti-cancer therapeutic drugs, many active small molecules that target histone acetylation regulatory enzymes or proteins such as histone deacetylases (HDACs), histone acetyltransferase (HATs) and bromodomains (BRDs) have been developed to restore abnormal histone acetylation levels to normal. In this review, we will focus on summarizing the changes of histone acetylation levels during tumorigenesis, as well as the possible pharmacological mechanisms of small molecules that target histone acetylation in cancer treatment.
Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Idioma: Inglês Revista: Front Oncol Ano de publicação: 2020 Tipo de documento: Artigo País de afiliação: China

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Idioma: Inglês Revista: Front Oncol Ano de publicação: 2020 Tipo de documento: Artigo País de afiliação: China