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Inhibiting phosphoglycerate dehydrogenase counteracts chemotherapeutic efficacy against MYCN-amplified neuroblastoma.
Arlt, Birte; Zasada, Christin; Baum, Katharina; Wuenschel, Jasmin; Mastrobuoni, Guido; Lodrini, Marco; Astrahantseff, Kathy; Winkler, Annika; Schulte, Johannes H; Finkler, Sabine; Forbes, Martin; Hundsdoerfer, Patrick; Guergen, Dennis; Hoffmann, Jens; Wolf, Jana; Eggert, Angelika; Kempa, Stefan; Deubzer, Hedwig E.
Afiliação
  • Arlt B; Department of Pediatric Hematology and Oncology, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.
  • Zasada C; Neuroblastoma Research Group, Experimental and Clinical Research Center (ECRC) of the Charité and the Max-Delbrück-Center for Molecular Medicine (MDC) in the Helmholtz Association, Lindenberger Weg 80, 13125, Berlin, Germany.
  • Baum K; Berliner Institut für Gesundheitsforschung (BIH), Anna-Louisa-Karsch-Straße 2, 10178, Berlin, Germany.
  • Wuenschel J; Integrative Proteomics and Metabolomics, Berlin Institute for Medical Systems Biology at the Max-Delbrück Center for Molecular Medicine in the Helmholtz Association, Hannoversche Str. 28, 10115, Berlin, Germany.
  • Mastrobuoni G; Integrative Proteomics and Metabolomics, Berlin Institute for Medical Systems Biology at the Max-Delbrück Center for Molecular Medicine in the Helmholtz Association, Hannoversche Str. 28, 10115, Berlin, Germany.
  • Lodrini M; Mathematical Modelling of Cellular Processes, Max-Delbrück Center for Molecular Medicine (MDC) in the Helmholtz Association, Robert-Rössle-Straße 10, 13125, Berlin, Germany.
  • Astrahantseff K; Department of Pediatric Hematology and Oncology, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.
  • Winkler A; Neuroblastoma Research Group, Experimental and Clinical Research Center (ECRC) of the Charité and the Max-Delbrück-Center for Molecular Medicine (MDC) in the Helmholtz Association, Lindenberger Weg 80, 13125, Berlin, Germany.
  • Schulte JH; Integrative Proteomics and Metabolomics, Berlin Institute for Medical Systems Biology at the Max-Delbrück Center for Molecular Medicine in the Helmholtz Association, Hannoversche Str. 28, 10115, Berlin, Germany.
  • Finkler S; Department of Pediatric Hematology and Oncology, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.
  • Forbes M; Neuroblastoma Research Group, Experimental and Clinical Research Center (ECRC) of the Charité and the Max-Delbrück-Center for Molecular Medicine (MDC) in the Helmholtz Association, Lindenberger Weg 80, 13125, Berlin, Germany.
  • Hundsdoerfer P; Department of Pediatric Hematology and Oncology, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.
  • Guergen D; Department of Pediatric Hematology and Oncology, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.
  • Hoffmann J; Department of Pediatric Hematology and Oncology, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.
  • Wolf J; Berliner Institut für Gesundheitsforschung (BIH), Anna-Louisa-Karsch-Straße 2, 10178, Berlin, Germany.
  • Eggert A; German Cancer Consortium (DKTK), Partner Site Berlin, Berlin, Germany.
  • Kempa S; German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Deubzer HE; Department of Pediatric Hematology and Oncology, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.
Int J Cancer ; 148(5): 1219-1232, 2021 03 01.
Article em En | MEDLINE | ID: mdl-33284994
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Amplificação de Genes / Fosfoglicerato Desidrogenase / Proteína Proto-Oncogênica N-Myc / Neuroblastoma Limite: Animals / Female / Humans Idioma: En Revista: Int J Cancer Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Alemanha País de publicação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Amplificação de Genes / Fosfoglicerato Desidrogenase / Proteína Proto-Oncogênica N-Myc / Neuroblastoma Limite: Animals / Female / Humans Idioma: En Revista: Int J Cancer Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Alemanha País de publicação: Estados Unidos