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Prevalence and factors associated with neonatal hypoglycemia in Northern Uganda: a community-based cross-sectional study.
Mukunya, David; Odongkara, Beatrice; Piloya, Thereza; Nankabirwa, Victoria; Achora, Vincentina; Batte, Charles; Ditai, James; Tylleskar, Thorkild; Ndeezi, Grace; Kiguli, Sarah; Tumwine, James K.
Afiliação
  • Mukunya D; Sanyu Africa Research Institute, Mbale, Uganda. zebdaevid@gmail.com.
  • Odongkara B; Center for Intervention Science in Maternal and Child Health (CISMAC), Center for International Health, University of Bergen, Bergen, Norway. zebdaevid@gmail.com.
  • Piloya T; Busitema University Faculty of Health Sciences, Mbale, Uganda. zebdaevid@gmail.com.
  • Nankabirwa V; Department of Pediatrics, University of Gulu, Gulu, Uganda.
  • Achora V; Center for International Health, University of Bergen, Bergen, Norway.
  • Batte C; Department of Pediatrics and Child Health, Makerere University, Kampala, Uganda.
  • Ditai J; Center for Intervention Science in Maternal and Child Health (CISMAC), Center for International Health, University of Bergen, Bergen, Norway.
  • Tylleskar T; Department of Epidemiology and Biostatistics, School of Public Health, Makerere University, Kampala, Uganda.
  • Ndeezi G; Department of Obstetrics and Gynecology, University of Gulu, Gulu, Uganda.
  • Kiguli S; Lung Institute, Makerere University, Kampala, Uganda.
  • Tumwine JK; Sanyu Africa Research Institute, Mbale, Uganda.
Trop Med Health ; 48(1): 89, 2020 Nov 04.
Artigo em Inglês | MEDLINE | ID: mdl-33292804
ABSTRACT

BACKGROUND:

Neonatal hypoglycemia is the most common endocrine abnormality in children, which is associated with increased morbidity and mortality. The burden and risk factors of neonatal hypoglycemia in rural communities in sub-Saharan Africa are unknown.

OBJECTIVE:

To determine the prevalence and risk factors for neonatal hypoglycemia in Lira District, Northern Uganda.

METHODS:

This was a community-based cross-sectional study, nested in a cluster randomized controlled trial designed to promote health facility births and newborn care practices in Lira District, Northern Uganda. This study recruited neonates born to mothers in the parent study. Random blood glucose was measured using an On Call® Plus glucometer (ACON Laboratories, Inc., 10125 Mesa Road, San Diego, CA, USA). We defined hypoglycemia as a blood glucose of < 47 mg/dl. To determine the factors associated with neonatal hypoglycemia, a multivariable linear regression mixed-effects model was used.

RESULTS:

We examined 1416 participants of mean age 3.1 days (standard deviation (SD) 2.1) and mean weight of 3.2 kg (SD 0.5). The mean neonatal blood glucose level was 81.6 mg/dl (SD 16.8). The prevalence of a blood glucose concentration of < 47 mg/dl was 2.2% (31/1416) 95% CI 1.2%, 3.9%. The risk factors for neonatal hypoglycemia were delayed breastfeeding initiation [adjusted mean difference, - 2.6; 95% CI, - 4.4, - 0.79] and child age of 3 days or less [adjusted mean, - 12.2; 95% CI, - 14.0, - 10.4].

CONCLUSION:

The incidence of neonatal hypoglycemia was low in this community and was predicted by delay in initiating breastfeeding and a child age of 3 days or less. We therefore suggest targeted screening and management of neonatal hypoglycemia among neonates before 3 days of age and those who are delayed in the onset of breastfeeding.
Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Idioma: Inglês Revista: Trop Med Health Ano de publicação: 2020 Tipo de documento: Artigo País de afiliação: Uganda

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Idioma: Inglês Revista: Trop Med Health Ano de publicação: 2020 Tipo de documento: Artigo País de afiliação: Uganda