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A biomimetically hierarchical polyetherketoneketone scaffold for osteoporotic bone repair.
Yuan, Bo; Wang, Linnan; Zhao, Rui; Yang, Xi; Yang, Xiao; Zhu, Xiangdong; Liu, Limin; Zhang, Kai; Song, Yueming; Zhang, Xingdong.
Afiliação
  • Yuan B; National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China.
  • Wang L; Department of Orthopaedics, West China Hospital of Sichuan University, Chengdu 610041, China.
  • Zhao R; National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China.
  • Yang X; Department of Orthopaedics, West China Hospital of Sichuan University, Chengdu 610041, China.
  • Yang X; National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China. xiaoyang114@scu.edu.cn zhu_xd1973@scu.edu.cn.
  • Zhu X; National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China. xiaoyang114@scu.edu.cn zhu_xd1973@scu.edu.cn.
  • Liu L; Department of Orthopaedics, West China Hospital of Sichuan University, Chengdu 610041, China.
  • Zhang K; National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China.
  • Song Y; Department of Orthopaedics, West China Hospital of Sichuan University, Chengdu 610041, China.
  • Zhang X; National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China.
Sci Adv ; 6(50)2020 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-33310848
ABSTRACT
Osteoporotic fractures are prevalent in society, and their incidence appears to be increasing as the worldwide population ages. However, conventional bone repair materials hardly satisfy the requirements for the repair of pathological fractures. Here, we developed a biomimetic polyetherketoneketone scaffold with a functionalized strontium-doped nanohydroxyapatite coating for osteoporotic bone defect applications. The scaffold has a hierarchically porous architecture and mechanical strength similar to that of osteoporotic trabecular bone. In vitro and in vivo studies demonstrated that the scaffold could promote osteoporotic bone regeneration and delay adjacent bone loss via regulating both osteoblasts and osteoclasts. In addition, the correlations between multiple preimplantation and postimplantation parameters were evaluated to determine the potential predictors of in vivo performance of the material. The current work not only develops a promising candidate for osteoporotic bone repair but also provides a viable approach for designing other functional biomaterials and predicting their translational value.
Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Idioma: Inglês Ano de publicação: 2020 Tipo de documento: Artigo País de afiliação: China

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Idioma: Inglês Ano de publicação: 2020 Tipo de documento: Artigo País de afiliação: China
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