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New lupus criteria: a critical view.
Aringer, Martin; Johnson, Sindhu R.
Afiliação
  • Aringer M; Division of Rheumatology, Department of Medicine III, University Medical Center and Faculty of Medicine Carl Gustav Carus at the TU Dresden, Dresden, Germany.
  • Johnson SR; Division of Rheumatology, Department of Medicine, Toronto Western Hospital, Mount Sinai Hospital.
Curr Opin Rheumatol ; 33(2): 205-210, 2021 Mar 01.
Artigo em Inglês | MEDLINE | ID: mdl-33332888
ABSTRACT
PURPOSE OF REVIEW To review the validation of the European League Against Rheumatism (EULAR)/American College of Rheumatology (ACR) 2019 classification criteria for systemic lupus erythematosus (SLE). RECENT

FINDINGS:

Positive antinuclear antibodies, which constitute the obligatory entry criterion of the EULAR/ACR criteria, were found in the vast majority of SLE patients worldwide, with 97% (94-100%) of patients antinuclear antibodies positive in studies investigating EULAR/ACR criteria performance. Combined over the publications, EULAR/ACR criteria sensitivity was 92% (range 85-97%). Specificity varied more relevantly, with the publications published after the EULAR/ACR 2019 criteria showing 93% (83-98%) specificity. Of particular relevance is the good performance of the EULAR/ACR criteria seen in pediatric SLE as well as in early SLE.

SUMMARY:

The new classification criteria have been investigated in an impressive number of cohorts worldwide, adding to the data from the EULAR/ACR criteria project cohort. It is critical to strictly keep to the attribution rule, that items are only counted if there is no more likely alternative explanation than SLE, the domain structure, where only the highest weighted item in a domain counts, and the limitation to highly specific tests for antibodies to double-stranded DNA.
Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Idioma: Inglês Revista: Curr Opin Rheumatol Assunto da revista: Reumatologia Ano de publicação: 2021 Tipo de documento: Artigo País de afiliação: Alemanha

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Idioma: Inglês Revista: Curr Opin Rheumatol Assunto da revista: Reumatologia Ano de publicação: 2021 Tipo de documento: Artigo País de afiliação: Alemanha