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SARS-CoV-2 nucleocapsid protein intranasal inoculation induces local and systemic T cell responses in mice.
He, Jia; Huang, Jing-Ru; Zhang, Yao-Lin; Zhang, Jiyan.
Afiliação
  • He J; Beijing Institute of Basic Medical Sciences, Beijing, China.
  • Huang JR; Beijing Institute of Basic Medical Sciences, Beijing, China.
  • Zhang YL; Beijing Institute of Basic Medical Sciences, Beijing, China.
  • Zhang J; Beijing Institute of Basic Medical Sciences, Beijing, China.
J Med Virol ; 93(4): 1923-1925, 2021 04.
Artigo em Inglês | MEDLINE | ID: mdl-33386773
ABSTRACT
SARS-CoV-2 nucleocapsid (N) protein has been proposed as a good vaccine target. N-specific T cells were observed in SARS-CoV-2 N immunized mice and COVID-19 convalescents. It is of importance to identify the T cell responses triggered by SARS-CoV-2 N protein. Intradermal immunization with SARS-CoV N protein was demonstrated to elicit non-protective T cell responses which may be avoided by intranasal vaccination. Therefore, we conducted intranasal vaccination of BALB/c mice with recombinant adenovirus type-5 expressing SARS-CoV-2 N protein. Such procedure induced CD8 T cell responses in the lung. Meanwhile CD4 T cell responses were observed in the spleen, which was associated with robust antibody production. Our study further supports the notion that SARS-CoV-2 N protein can work as a target for vaccine development.
Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Idioma: Inglês Revista: J Med Virol Ano de publicação: 2021 Tipo de documento: Artigo País de afiliação: China

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Idioma: Inglês Revista: J Med Virol Ano de publicação: 2021 Tipo de documento: Artigo País de afiliação: China