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Carotid intima-media thickness and serum proinflammatory cytokine levels in rosacea patients without cardiovascular risk factors.
Ertekin, Sümeyre Seda; Koku Aksu, Ayse Esra; Koçyigit, Abdurrahim; Güler, Eray Metin; Baykara Ulusan, Melis; Gürel, Mehmet Salih.
Afiliação
  • Ertekin SS; Department of Dermatology, Istanbul Training and Research Hospital, Health Science University, Istanbul, Turkey.
  • Koku Aksu AE; Department of Dermatology, Aksaray University, Aksaray Training and Research Hospital, Aksaray, Turkey.
  • Koçyigit A; Department of Dermatology, Istanbul Training and Research Hospital, Health Science University, Istanbul, Turkey.
  • Güler EM; Department of Biochemistry, Bezmialem Vakif University Medical School, Istanbul, Turkey.
  • Baykara Ulusan M; Department of Biochemistry, Bezmialem Vakif University Medical School, Istanbul, Turkey.
  • Gürel MS; Department of Biochemistry, Hamidiye Medicine Faculty, Health Science University, Istanbul, Turkey.
Dermatol Ther ; 34(1): e14733, 2021 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-33389789
ABSTRACT
There is a growing body of evidence linking rosacea to various systemic disorders, even though data regarding the association between rosacea and cardiovascular diseases are presently controversial. We sought to investigate the potential association of rosacea with subclinical atherosclerosis and serum proinflammatory/proatherogenic markers. This study included 44 patients with rosacea and 44 age-matched and sex-matched healthy control subjects. Patients with traditional cardiovascular risk factors or a history of cardiovascular events were excluded. Demographic, clinical, and laboratory data, including serum interleukin-1 beta (IL-1ß), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and high-sensitivity C-reactive protein (hs-CRP) levels were assessed. Carotid intima-media thickness (CIMT) and carotid plaques were measured by carotid ultrasonography. Serum IL-1ß (P < .001), IL-6 (P < .001), TNF-α (P < .001), and hs-CRP (P < .001) levels were significantly higher in the patient group compared with the control group. Mean CIMT values did not differ significantly between the patient group and control group (P > .05). Patients with moderate to severe rosacea had a significantly greater CIMT than those with mild rosacea (P = .047). Rosacea patients with eye involvement had a significantly greater CIMT than those without eye involvement (P = .008). There was no significant correlation between CIMT values and inflammation parameters. As conclusion, in the absence of other traditional cardiovascular risk factors, rosacea does not seem to affect mean CIMT value. However, specific subgroups such as patients with moderate to severe disease or with eye involvement are associated with increased subclinical atherosclerosis and may require additional attention for cardiovascular disease prevention.
Texto completo: Disponível Coleções: Bases de dados internacionais Contexto em Saúde: ODS3 - Saúde e Bem-Estar Tema em saúde: Meta 3.4: Reduzir as mortes prematuras devido doenças não transmissíveis Base de dados: MEDLINE Tipo de estudo: Estudo de etiologia / Estudo observacional / Fatores de risco Idioma: Inglês Revista: Dermatol Ther Assunto da revista: Dermatologia Ano de publicação: 2021 Tipo de documento: Artigo País de afiliação: Turquia

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Texto completo: Disponível Coleções: Bases de dados internacionais Contexto em Saúde: ODS3 - Saúde e Bem-Estar Tema em saúde: Meta 3.4: Reduzir as mortes prematuras devido doenças não transmissíveis Base de dados: MEDLINE Tipo de estudo: Estudo de etiologia / Estudo observacional / Fatores de risco Idioma: Inglês Revista: Dermatol Ther Assunto da revista: Dermatologia Ano de publicação: 2021 Tipo de documento: Artigo País de afiliação: Turquia