Your browser doesn't support javascript.
loading
A Southeast Asian Perspective on the COVID-19 Pandemic: Hemoglobin E (HbE)-Trait Confers Resistance Against COVID-19.
Papadopoulos, Konstantinos I; Sutheesophon, Warachaya; Manipalviratn, Somjate; Aw, Tar-Choon.
Afiliação
  • Papadopoulos KI; Department of Research and Development, THAI StemLife Co. Ltd., Bangkok, Thailand.
  • Sutheesophon W; Laboratory Department, THAI StemLife Co. Ltd., Bangkok, Thailand.
  • Manipalviratn S; Department of Reproductive Endocrinology, Jetanin Institute for Assisted Reproduction, Bangkok, Thailand.
  • Aw TC; Department of Laboratory Medicine, Changi General Hospital, Singapore, Singapore.
Med Sci Monit Basic Res ; 27: e929207, 2021 Jan 05.
Artigo em Inglês | MEDLINE | ID: mdl-33397841
ABSTRACT
As of November 25, 2020, over 60 million people have been infected worldwide by COVID-19, causing almost 1.43 million deaths. Puzzling low incidence numbers and milder, non-fatal disease have been observed in Thailand and its Southeast (SE) Asian neighbors. Elusive genetic mechanisms might be operative, as a multitude of genetic factors are widely shared between the SE Asian populations, such as the more than 60 different thalassemia syndromes (principally dominated by the HbE trait). In this study, we have plotted COVID-19 infection and death rates in SE Asian (SEA) countries against heterozygote HbE and thalassemia carrier prevalence. COVID-19 infection and death incidence numbers appear inversely correlated with the prevalence of HbE and thalassemia heterozygote populations. We posit that the evolutionary protective effect of the HbE and other thalassemic variants against malaria and the dengue virus may extend its advantage to resistance to COVID-19 infection, as HbE heterozygote population prevalence appears to be positively correlated with immunity to COVID-19. Host immune system modulations induce antiviral interferon responses and alter structural protein integrity, thereby inhibiting cellular access and viral replication. These changes are possibly engendered by HbE carrier miRNAs. Proving this hypothesis is important, as it may shed light on the mechanism of viral resistance and lead to novel antiviral treatments. This development can thus guide decision-making and action to prevent COVID-19 infection.
Assuntos
Texto completo: Disponível Coleções: Bases de dados internacionais Contexto em Saúde: Doenças Neglicenciadas Tema em saúde: Malária Base de dados: MEDLINE Assunto principal: Hemoglobina E / Suscetibilidade a Doenças / Resistência à Doença Tipo de estudo: Estudo de prevalência / Estudo prognóstico / Fatores de risco Limite: Humanos País/Região como assunto: Ásia Idioma: Inglês Revista: Med Sci Monit Basic Res Ano de publicação: 2021 Tipo de documento: Artigo País de afiliação: Tailândia

Similares

MEDLINE

...
LILACS

LIS

Texto completo: Disponível Coleções: Bases de dados internacionais Contexto em Saúde: Doenças Neglicenciadas Tema em saúde: Malária Base de dados: MEDLINE Assunto principal: Hemoglobina E / Suscetibilidade a Doenças / Resistência à Doença Tipo de estudo: Estudo de prevalência / Estudo prognóstico / Fatores de risco Limite: Humanos País/Região como assunto: Ásia Idioma: Inglês Revista: Med Sci Monit Basic Res Ano de publicação: 2021 Tipo de documento: Artigo País de afiliação: Tailândia
...