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Spherical Nucleic Acids for Topical Treatment of Hyperpigmentation.
Fang, Yang; Lu, Xueguang; Wang, Dali; Cai, Jiansong; Wang, Yuyan; Chen, Peiru; Ren, Mengqi; Lu, Hao; Union, Jennifer; Zhang, Lei; Sun, Yehui; Jia, Fei; Kang, Xi; Tan, Xuyu; Zhang, Ke.
Afiliação
  • Fang Y; Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States.
  • Lu X; Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.
  • Wang D; Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States.
  • Cai J; Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States.
  • Wang Y; Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States.
  • Chen P; Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States.
  • Ren M; Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States.
  • Lu H; Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States.
  • Union J; Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States.
  • Zhang L; Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States.
  • Sun Y; Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States.
  • Jia F; Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States.
  • Kang X; Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States.
  • Tan X; Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States.
  • Zhang K; Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.
J Am Chem Soc ; 143(3): 1296-1300, 2021 Jan 27.
Artigo em Inglês | MEDLINE | ID: mdl-33433203
ABSTRACT
Oligonucleotide-based materials such as spherical nucleic acid (SNA) have been reported to exhibit improved penetration through the epidermis and the dermis of the skin upon topical application. Herein, we report a self-assembled, skin-depigmenting SNA structure, which is based upon a bifunctional oligonucleotide amphiphile containing an antisense oligonucleotide and a tyrosinase inhibitor prodrug. The two components work synergistically to increase oligonucleotide cellular uptake, enhance drug solubility, and promote skin penetration. The particles were shown to reduce melanin content in B16F10 melanoma cells and exhibited a potent antimelanogenic effect in an ultraviolet B-induced hyperpigmentation mouse model.
Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Idioma: Inglês Revista: J Am Chem Soc Ano de publicação: 2021 Tipo de documento: Artigo País de afiliação: Estados Unidos

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Idioma: Inglês Revista: J Am Chem Soc Ano de publicação: 2021 Tipo de documento: Artigo País de afiliação: Estados Unidos