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Increased levels of pentraxins protein and cytokines bear good association in patients with severe dengue infection.
Patra, Goutam; Saha, Bibhuti; Mukhopadhyay, Sumi.
Afiliação
  • Patra G; Department of Laboratory Medicine, Calcutta School of Tropical Medicine, Kolkata, West Bengal, India.
  • Saha B; Department of Tropical Medicine, Calcutta School of Tropical Medicine, Kolkata, West Bengal, India.
  • Mukhopadhyay S; Department of Laboratory Medicine, Calcutta School of Tropical Medicine, Kolkata, West Bengal, India. drsumimukhopadhyay@gmail.com.
Sci Rep ; 11(1): 511, 2021 Jan 12.
Artigo em Inglês | MEDLINE | ID: mdl-33436908
ABSTRACT
Dengue is an arboviral infection with high rates of morbidity and mortality throughout the tropics and sub-tropics. This work studied the status of pentraxin (CRP/SAP) protein, ferritin, TNF-α and IL-1ß levels in Dengue patients of different pathophysiological manifestations. Accordingly, clinically confirmed Dengue cases (n = 97) were enrolled and subsequently blood parameters were studied by Haematology cell counter and Biochemistry Autoanalyser. CRP, SAP, ferritin, TNF-α and IL-1ß ELISA were done in all the samples by using standard ELISA kits. Statistical Analysis was done in all the experiments. The levels of CRP (p < 0.0001), SAP (p < 0.0001), ferritin (p < 0.0001), TNF-α (p < 0.0001) and IL-1ß (p < 0.0001) were high in patients with Severe Dengue as compared to Dengue without warning signs. High levels of SGOT, SGPT and decreased platelet counts were found in severe patients as compared to Healthy donor. CRP/SAP as well as TNF-α/IL-1ß were independently associated with both dengue severity and overall disease manifestation. Statistically significant increased CRP, SAP, ferritin, TNF-α and IL-1ß titres were correlated in patients with severe clinical manifestations as compared to mild disease forms of dengue. Elevated levels of pentraxin, TNF-α/IL-1ß in blood during dengue infection could act as an early predictor in Severe Dengue infection.
Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Tipo de estudo: Fatores de risco Idioma: Inglês Revista: Sci Rep Ano de publicação: 2021 Tipo de documento: Artigo País de afiliação: Índia

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Tipo de estudo: Fatores de risco Idioma: Inglês Revista: Sci Rep Ano de publicação: 2021 Tipo de documento: Artigo País de afiliação: Índia
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