Protective effects of resveratrol against the cardiac developmental toxicity of trichloroethylene in zebrafish embryos.
Toxicology
; 452: 152697, 2021 03 30.
Article
em En
| MEDLINE
| ID: mdl-33524428
ABSTRACT
Trichloroethylene (TCE), a prevalent environmental contaminant, has been shown to induce cardiac malformations. Resveratrol (RSV) is a natural polyphenolic compound exhibiting protective effects on heart development. To investigate if RSV could protect against TCE-induced heart defects, we exposed zebrafish embryos to TCE (10 ppb) in the presence or absence of RSV (1 µg/mL). Our results showed that RSV significantly attenuated TCE-induced heart defects in zebrafish embryos. The TCE-induced ROS (reactive oxygen species) generation, 8-OHdG (8-hydroxy-2`-deoxyguanosine) formation and cell proliferation were significantly counteracted by RSV. Moreover, RSV attenuated the TCE-induced changes in mRNA expression or activity of genes involved in AHR and Nrf2 signal pathways. We further showed that RSV might inhibit TCE-enhanced cell proliferation by rescuing the downregulation of the p53/p21 axis. In conclusion, our data demonstrates that RSV protects against the cardiac developmental toxicity of TCE by inhibiting AHR activity, oxidative stress and cell proliferation.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tricloroetileno
/
Cardiotônicos
/
Desenvolvimento Embrionário
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Resveratrol
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Coração
Limite:
Animals
Idioma:
En
Revista:
Toxicology
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
China
País de publicação:
IE
/
IRELAND
/
IRLANDA