Population pharmacokinetics and genetics of oral meltdose tacrolimus (Envarsus) in stable adult liver transplant recipients.

Martial, Lisa C; Biewenga, Maaike; Ruijter, Bastian N; Keizer, Ron; Swen, Jesse J; van Hoek, Bart; Moes, Dirk Jan A R

Martial, Lisa C; Biewenga, Maaike; Ruijter, Bastian N; Keizer, Ron; Swen, Jesse J; van Hoek, Bart; Moes, Dirk Jan A R.

Afiliação

Martial LC; Department of Clinical Pharmacy and Toxicology, Leiden University Medical Centre, Leiden, Netherlands.
Biewenga M; Department of Gastroenterology and Hepatology, Leiden University Medical Centre, Leiden, Netherlands.
Ruijter BN; Department of Gastroenterology and Hepatology, Leiden University Medical Centre, Leiden, Netherlands.
Keizer R; InsightRX, San Francisco, CA, USA.
Swen JJ; Department of Clinical Pharmacy and Toxicology, Leiden University Medical Centre, Leiden, Netherlands.
van Hoek B; Department of Gastroenterology and Hepatology, Leiden University Medical Centre, Leiden, Netherlands.
Moes DJAR; Department of Clinical Pharmacy and Toxicology, Leiden University Medical Centre, Leiden, Netherlands.

Br J Clin Pharmacol ; 87(11): 4262-4272, 2021 11.

Article em En | MEDLINE | ID: mdl-33786892

Assuntos

Transplante de Fígado; Tacrolimo; Adulto; Citocromo P-450 CYP3A/genética; Genótipo; Humanos; Imunossupressores; Taxa de Depuração Metabólica; Modelos Biológicos; Doadores de Tecidos; Transplantados

Palavras-chave

population pharmacokinetics; tacrolimus; therapeutic drug monitoring

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transplante de Fígado / Tacrolimo Tipo de estudo: Prognostic_studies Limite: Adult / Humans Idioma: En Revista: Br J Clin Pharmacol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Holanda País de publicação: Reino Unido

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