Measurement of the Intracellular Mycobacterium tuberculosis Drug Effect and Prediction of the Clinical Dose-Response Relationship Using Intracellular Pharmacodynamic Modeling (PD<sub>i</sub>).

Donnellan, Samantha; Martínez-Rodríguez, Carmen; Aljayyoussi, Ghaith; Biagini, Giancarlo A

Measurement of the Intracellular Mycobacterium tuberculosis Drug Effect and Prediction of the Clinical Dose-Response Relationship Using Intracellular Pharmacodynamic Modeling (PD_i).

Donnellan, Samantha; Martínez-Rodríguez, Carmen; Aljayyoussi, Ghaith; Biagini, Giancarlo A.

Afiliação

Donnellan S; Centre for Drugs and Diagnostics, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, UK. Samantha.donnellan@lstmed.ac.uk.
Martínez-Rodríguez C; Clinical Infection, Microbiology and Immunology, Institute of Infection and Global Health, The University of Liverpool, Liverpool, UK.
Aljayyoussi G; Centre for Drugs and Diagnostics, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, UK.
Biagini GA; Centre for Drugs and Diagnostics, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, UK.

Methods Mol Biol ; 2296: 393-408, 2021.

Article em En | MEDLINE | ID: mdl-33977461

Assuntos

Antituberculosos/farmacologia; Mycobacterium tuberculosis/efeitos dos fármacos; Tuberculose/tratamento farmacológico; Proteínas de Bactérias/metabolismo; Relação Dose-Resposta a Droga; Desenvolvimento de Medicamentos/métodos; Humanos; Mycobacterium tuberculosis/metabolismo; Células THP-1

Palavras-chave

Antibiotics; Drug screening; Mycobacteria; Pharmacokinetic and pharmacodynamic drug Modeling; Tuberculosis

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tuberculose / Mycobacterium tuberculosis / Antituberculosos Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Methods Mol Biol Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Reino Unido País de publicação: Estados Unidos

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google