Trefoil factor 2 secreted from damaged hepatocytes activates hepatic stellate cells to induce fibrogenesis.

Zhang, Bichen; Lapenta, Kalina; Wang, Qi; Nam, Jin Hyun; Chung, Dongjun; Robert, Marie E; Nathanson, Michael H; Yang, Xiaoyong

Zhang, Bichen; Lapenta, Kalina; Wang, Qi; Nam, Jin Hyun; Chung, Dongjun; Robert, Marie E; Nathanson, Michael H; Yang, Xiaoyong.

Afiliação

Zhang B; Department of Cellular and Molecular Physiology, Yale University, New Haven, Connecticut, USA.
Lapenta K; Program in Integrative Cell Signaling and Neurobiology of Metabolism, Department of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
Wang Q; Department of Cellular and Molecular Physiology, Yale University, New Haven, Connecticut, USA.
Nam JH; Department of Public Health Sciences, Medical University of South Carolina, Charleston, South Carolina, USA.
Chung D; Department of Biomedical Informatics, College of Medicine, Ohio State University, Columbus, Ohio, USA.
Robert ME; Department of Pathology, Yale University School of Medicine, New Haven, Connecticut, USA.
Nathanson MH; Section of Digestive Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
Yang X; Department of Cellular and Molecular Physiology, Yale University, New Haven, Connecticut, USA; Program in Integrative Cell Signaling and Neurobiology of Metabolism, Department of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut, USA. Electronic address: xiaoyong.yang@

J Biol Chem ; 297(1): 100887, 2021 07.

Article em En | MEDLINE | ID: mdl-34146542

Assuntos

Células Estreladas do Fígado/metabolismo; Hepatócitos/metabolismo; Cirrose Hepática/metabolismo; Fator Trefoil-2/metabolismo; Animais; Tetracloreto de Carbono/toxicidade; Linhagem Celular; Células Cultivadas; Exocitose; Células Estreladas do Fígado/patologia; Hepatócitos/patologia; Humanos; Cirrose Hepática/etiologia; Camundongos; N-Acetilglucosaminiltransferases/deficiência; N-Acetilglucosaminiltransferases/genética; N-Acetilglucosaminiltransferases/metabolismo; Necroptose; Transdução de Sinais; Fator Trefoil-2/genética

Palavras-chave

OGT; PDGFRß; hepatic stellate cell; intercellular signaling; liver fibrosis; trefoil factor 2

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hepatócitos / Células Estreladas do Fígado / Fator Trefoil-2 / Cirrose Hepática Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Animals / Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos

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