A schizophrenia risk factor induces marked anatomical deficits at GABAergic-dopaminergic synapses in the rat ventral tegmental area: Essential evidence for new targeted therapies.

Seo, Steve; Sizemore, Rachel J; Reader, Karen L; Smither, Roseanna A; Wicky, Hollie E; Hughes, Stephanie M; Bilkey, David K; Parr-Brownlie, Louise C; Oorschot, Dorothy E

Seo, Steve; Sizemore, Rachel J; Reader, Karen L; Smither, Roseanna A; Wicky, Hollie E; Hughes, Stephanie M; Bilkey, David K; Parr-Brownlie, Louise C; Oorschot, Dorothy E.

Afiliação

Seo S; Department of Anatomy, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand.
Sizemore RJ; Brain Health Research Centre, University of Otago, Dunedin, New Zealand.
Reader KL; Department of Anatomy, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand.
Smither RA; Brain Health Research Centre, University of Otago, Dunedin, New Zealand.
Wicky HE; Department of Anatomy, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand.
Hughes SM; Brain Health Research Centre, University of Otago, Dunedin, New Zealand.
Bilkey DK; Department of Anatomy, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand.
Parr-Brownlie LC; Brain Health Research Centre, University of Otago, Dunedin, New Zealand.
Oorschot DE; Brain Research, New Zealand.

J Comp Neurol ; 529(18): 3946-3973, 2021 12.

Article em En | MEDLINE | ID: mdl-34338311

Assuntos

Neurônios Dopaminérgicos/fisiologia; Neurônios GABAérgicos/fisiologia; Terminações Pré-Sinápticas/metabolismo; Esquizofrenia/fisiopatologia; Sinapses/metabolismo; Área Tegmentar Ventral/metabolismo; Animais; Masculino; Microscopia Eletrônica de Transmissão; Ratos; Fatores de Risco

Palavras-chave

axoaxodendritic synapses; dopaminergic posterior ventral tegmental neurons; immunonanogold; maternal immune activation; rostromedial tegmental GABAergic neurons; serial section transmission electron microscopy

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Esquizofrenia / Sinapses / Área Tegmentar Ventral / Terminações Pré-Sinápticas / Neurônios Dopaminérgicos / Neurônios GABAérgicos Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: J Comp Neurol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Nova Zelândia País de publicação: Estados Unidos

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