Adipose tissue macrophage-derived exosomes induce ferroptosis via glutathione synthesis inhibition by targeting SLC7A11 in obesity-induced cardiac injury.

Zhao, Xin; Si, Linjie; Bian, Jinhui; Pan, Chunfeng; Guo, Wen; Qin, Pei; Zhu, Wenfang; Xia, Yang; Zhang, Qun; Wei, Ke

Zhao, Xin; Si, Linjie; Bian, Jinhui; Pan, Chunfeng; Guo, Wen; Qin, Pei; Zhu, Wenfang; Xia, Yang; Zhang, Qun; Wei, Ke.

Afiliação

Zhao X; Department of Health Management Center, The First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, Jiangsu, China.
Si L; Department of Cardiovascular Surgery, The First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, Jiangsu, China.
Bian J; Department of Cardiovascular Surgery, The First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, Jiangsu, China.
Pan C; Department of Thoracic Surgery, The First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, Jiangsu, China.
Guo W; Department of Health Management Center, The First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, Jiangsu, China.
Qin P; Department of Health Management Center, The First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, Jiangsu, China.
Zhu W; Department of Health Management Center, The First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, Jiangsu, China.
Xia Y; Department of Thoracic Surgery, The First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, Jiangsu, China. Electronic address: xiayang-1019@njmu.edu.cn.
Zhang Q; Department of Health Management Center, The First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, Jiangsu, China. Electronic address: wenzi20100305@126.com.
Wei K; Department of Thoracic Surgery, The First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, Jiangsu, China. Electronic address: weike0727@njmu.edu.cn.

Free Radic Biol Med ; 182: 232-245, 2022 03.

Article em En | MEDLINE | ID: mdl-35271999

Assuntos

Exossomos; Ferroptose; MicroRNAs; Tecido Adiposo/metabolismo; Sistema y+ de Transporte de Aminoácidos; Animais; Exossomos/genética; Exossomos/metabolismo; Ferroptose/genética; Glutationa/metabolismo; Macrófagos/metabolismo; Camundongos; MicroRNAs/genética; MicroRNAs/metabolismo; Obesidade/genética; Obesidade/metabolismo

Palavras-chave

Adipose tissue macrophage; Exosomes; Ferroptosis; Obesity-induced cardiac injury

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: MicroRNAs / Exossomos / Ferroptose Limite: Animals Idioma: En Revista: Free Radic Biol Med Assunto da revista: BIOQUIMICA / MEDICINA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China País de publicação: Estados Unidos

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