CRISPR/Cas gene editing in the human germline.

Bekaert, B; Boel, A; Cosemans, G; De Witte, L; Menten, B; Heindryckx, B

Bekaert, B; Boel, A; Cosemans, G; De Witte, L; Menten, B; Heindryckx, B.

Afiliação

Bekaert B; Ghent-Fertility And Stem cell Team (G-FaST), Department for Reproductive Medicine, Ghent University Hospital, Corneel Heymanslaan 10, 9000 Ghent, Belgium.
Boel A; Ghent-Fertility And Stem cell Team (G-FaST), Department for Reproductive Medicine, Ghent University Hospital, Corneel Heymanslaan 10, 9000 Ghent, Belgium.
Cosemans G; Ghent-Fertility And Stem cell Team (G-FaST), Department for Reproductive Medicine, Ghent University Hospital, Corneel Heymanslaan 10, 9000 Ghent, Belgium.
De Witte L; Center for Medical Genetics Ghent, Ghent University, Department of Biomolecular Medicine, Corneel Heymanslaan 10, 9000 Ghent, Belgium.
Menten B; Center for Medical Genetics Ghent, Ghent University, Department of Biomolecular Medicine, Corneel Heymanslaan 10, 9000 Ghent, Belgium.
Heindryckx B; Ghent-Fertility And Stem cell Team (G-FaST), Department for Reproductive Medicine, Ghent University Hospital, Corneel Heymanslaan 10, 9000 Ghent, Belgium. Electronic address: Bjorn.Heindryckx@UGent.be.

Semin Cell Dev Biol ; 131: 93-107, 2022 11.

Article em En | MEDLINE | ID: mdl-35305903

Assuntos

Sistemas CRISPR-Cas; Edição de Genes; Animais; Sistemas CRISPR-Cas/genética; Feminino; Células Germinativas; Humanos; Mosaicismo; Oócitos; Gravidez

Palavras-chave

Base editing; CRISPR/Cas9; Human germline gene editing; Loss-of-heterozygosity; Mosaicism; Prime editing

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sistemas CRISPR-Cas / Edição de Genes Tipo de estudo: Prognostic_studies Aspecto: Ethics Limite: Animals / Female / Humans / Pregnancy Idioma: En Revista: Semin Cell Dev Biol Assunto da revista: EMBRIOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Bélgica País de publicação: Reino Unido

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