Dual role of neddylation in transcription of hepatitis B virus RNAs from cccDNA and production of viral surface antigen.

Qu, Bingqian; Nebioglu, Firat; Leuthold, Mila M; Ni, Yi; Mutz, Pascal; Beneke, Jürgen; Erfle, Holger; Vondran, Florian W R; Bartenschlager, Ralf; Urban, Stephan

Qu, Bingqian; Nebioglu, Firat; Leuthold, Mila M; Ni, Yi; Mutz, Pascal; Beneke, Jürgen; Erfle, Holger; Vondran, Florian W R; Bartenschlager, Ralf; Urban, Stephan.

Afiliação

Qu B; Department of Infectious Diseases, Molecular Virology, Heidelberg University, Heidelberg, Germany.
Nebioglu F; Division of Veterinary Medicine, Paul Ehrlich Institute, Langen, Germany.
Leuthold MM; Department of Infectious Diseases, Molecular Virology, Heidelberg University, Heidelberg, Germany.
Ni Y; Division of Virus-Associated Carcinogenesis (F170), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Mutz P; Department of Infectious Diseases, Molecular Virology, Heidelberg University, Heidelberg, Germany.
Beneke J; Department of Infectious Diseases, Molecular Virology, Heidelberg University, Heidelberg, Germany.
Erfle H; German Center for Infection Research (DZIF), Heidelberg Partner site, Heidelberg, Germany.
Vondran FWR; Department of Infectious Diseases, Molecular Virology, Heidelberg University, Heidelberg, Germany.
Bartenschlager R; Division of Virus-Associated Carcinogenesis (F170), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Urban S; Advanced Biological Screening Facility Center for Quantitative Analysis of Molecular and Cellular Biosystems (BioQuant), Heidelberg University, Heidelberg, Germany.

JHEP Rep ; 4(10): 100551, 2022 Oct.

Article em En | MEDLINE | ID: mdl-36124123

Palavras-chave

DDB1, DNA damage-binding protein 1; HBsAg; HBsAg, hepatitis B virus surface antigen; HBx; HBx, hepatitis B virus X protein; MLN4924; NAE1, NEDD8-activating enzyme E1 subunit 1; NEDD8, neural precursor cell expressed, developmentally downregulated 8; PHHs, primary human hepatocytes; SMC6; SVP, subviral particles; Smc5/6, structural maintenance of chromosomes 5/6; WT, wild-type; cccDNA; cccDNA, covalently closed circular DNA; integrants; neddylation; pgRNA, pregenomic RNA; siRNA, small-interfering RNA; transcription

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: JHEP Rep Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Alemanha País de publicação: Holanda

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