Depletion of growth differentiation factor 15 (GDF15) leads to mitochondrial dysfunction and premature senescence in human dermal fibroblasts.
Aging Cell
; 22(1): e13752, 2023 01.
Article
em En
| MEDLINE
| ID: mdl-36547021
ABSTRACT
Growth differentiation factor 15 (GDF15) is a stress-responsive cytokine also known as a mitokine; however, its role in mitochondrial homeostasis and cellular senescence remained elusive. We show here that knocking down GDF15 expression in human dermal fibroblasts induced mitochondrial dysfunction and premature senescence, associated with a distinct senescence-associated secretory phenotype. Fibroblast-specific loss of GDF15 expression in a model of 3D reconstructed human skin induced epidermal thinning, a hallmark of skin aging. Our results suggest GDF15 to play a so far undisclosed role in mitochondrial homeostasis to delay both the onset of cellular senescence and the appearance of age-related changes in a 3D human skin model.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pele
/
Fator 15 de Diferenciação de Crescimento
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Aging Cell
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Áustria