A Promising Biomolecule Able to Degrade Neutrophil Extracellular Traps: CdcPDE, a Rattlesnake Phosphodiesterase.
Toxins (Basel)
; 15(1)2023 01 05.
Article
em En
| MEDLINE
| ID: mdl-36668864
ABSTRACT
Neutrophil extracellular traps (NETs) are an important mechanism for defense against pathogens. Their overproduction can be harmful since excessive NET formation promotes inflammation and tissue damage in several diseases. Nucleases are capable to degrade NET on basis of their DNA hydrolysis activity, including the CdcPDE, a nuclease isolated from Crotalus durissus collilineatus snake venom. Here, we report a new finding about CdcPDE activity, demonstrating its efficiency in degrading cell-free DNA from NETs, being a potential candidate to assist in therapies targeting inflammatory diseases.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Armadilhas Extracelulares
Limite:
Animals
Idioma:
En
Revista:
Toxins (Basel)
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Brasil