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Structure-Activity Relationships of Flupirtine Analogues for Liver Esterase-Mediated Cleavage of the 4-Fluorobenzylamine Moiety and Its Possible Relevance to Liver Toxicity.
Beirow, Kristin; Jedamzik, Julia; Schulig, Lukas; Wurm, Konrad W; Lemmerhirt, Christian J; Hofstetter, Robert K; Link, Andreas; Bednarski, Patrick J.
Afiliação
  • Beirow K; Department of Pharmaceutical/Medicinal Chemistry Institute of Pharmacy, University of Greifswald, Friedrich-Ludwig-Jahn-Str. 17, 17489, Greifswald, Germany.
  • Jedamzik J; Department of Pharmaceutical/Medicinal Chemistry Institute of Pharmacy, University of Greifswald, Friedrich-Ludwig-Jahn-Str. 17, 17489, Greifswald, Germany.
  • Schulig L; Department of Pharmaceutical/Medicinal Chemistry Institute of Pharmacy, University of Greifswald, Friedrich-Ludwig-Jahn-Str. 17, 17489, Greifswald, Germany.
  • Wurm KW; Department of Pharmaceutical/Medicinal Chemistry Institute of Pharmacy, University of Greifswald, Friedrich-Ludwig-Jahn-Str. 17, 17489, Greifswald, Germany.
  • Lemmerhirt CJ; Department of Pharmaceutical/Medicinal Chemistry Institute of Pharmacy, University of Greifswald, Friedrich-Ludwig-Jahn-Str. 17, 17489, Greifswald, Germany.
  • Hofstetter RK; Department of Pharmaceutical/Medicinal Chemistry Institute of Pharmacy, University of Greifswald, Friedrich-Ludwig-Jahn-Str. 17, 17489, Greifswald, Germany.
  • Link A; Present address: Department of Pharmaceutical/Medicinal Chemistry Institute of Pharmacy, Friedrich-Schiller-University Jena, Philosophenweg 14, 07743, Jena, Germany.
  • Bednarski PJ; Department of Pharmaceutical/Medicinal Chemistry Institute of Pharmacy, University of Greifswald, Friedrich-Ludwig-Jahn-Str. 17, 17489, Greifswald, Germany.
ChemMedChem ; 18(14): e202300145, 2023 07 17.
Article em En | MEDLINE | ID: mdl-37170841
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Esterases / Doença Hepática Induzida por Substâncias e Drogas Limite: Humans Idioma: En Revista: ChemMedChem Assunto da revista: FARMACOLOGIA / QUIMICA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Alemanha País de publicação: Alemanha
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Esterases / Doença Hepática Induzida por Substâncias e Drogas Limite: Humans Idioma: En Revista: ChemMedChem Assunto da revista: FARMACOLOGIA / QUIMICA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Alemanha País de publicação: Alemanha