Ruxolitinib inhibits the proliferation and induces the apoptosis of MLL-r ALL cells through inactivating JAK/STAT signaling pathway.

Liao, Xiong-Yu; Zhou, Dun-Hua; Fang, Jian-Pei; Qiu, Kun-Yin

Liao, Xiong-Yu; Zhou, Dun-Hua; Fang, Jian-Pei; Qiu, Kun-Yin.

Afiliação

Liao XY; Department of Hematology/Oncology, Children's Medical Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
Zhou DH; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
Fang JP; Department of Hematology/Oncology, Children's Medical Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
Qiu KY; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.

Transl Pediatr ; 12(6): 1088-1097, 2023 Jun 30.

Article em En | MEDLINE | ID: mdl-37427069

Palavras-chave

JAK/STAT; Ruxolitinib; acute lymphoblastic leukemia (ALL); mixed-lineage leukemia rearrangement (MLL-r); signaling pathway

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Transl Pediatr Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China País de publicação: China

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