Developmental toxicity of flufenacet including vascular, liver, and pancreas defects is mediated by apoptosis and alters the Mapk and PI3K/Akt signal transduction in zebrafish.

An, Garam; Park, Junho; You, Jeankyoung; Park, Hahyun; Hong, Taeyeon; Lim, Whasun; Song, Gwonhwa

An, Garam; Park, Junho; You, Jeankyoung; Park, Hahyun; Hong, Taeyeon; Lim, Whasun; Song, Gwonhwa.

Afiliação

An G; Institute of Animal Molecular Biotechnology and Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea.
Park J; Institute of Animal Molecular Biotechnology and Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea.
You J; Institute of Animal Molecular Biotechnology and Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea.
Park H; Institute of Animal Molecular Biotechnology and Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea.
Hong T; Department of Biological Sciences, Sungkyunkwan University, Suwon 16419, Republic of Korea.
Lim W; Department of Biological Sciences, Sungkyunkwan University, Suwon 16419, Republic of Korea. Electronic address: wlim@skku.edu.
Song G; Institute of Animal Molecular Biotechnology and Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea. Electronic address: ghsong@korea.ac.kr.

Comp Biochem Physiol C Toxicol Pharmacol ; 273: 109735, 2023 Nov.

Article em En | MEDLINE | ID: mdl-37659609

Assuntos

Fosfatidilinositol 3-Quinases; Peixe-Zebra; Animais; Proteínas Proto-Oncogênicas c-akt; Ecossistema; Fígado; Pâncreas; Apoptose; Transdução de Sinais

Palavras-chave

Embryotoxicity; Flufenacet; Hepatopancreatic toxicity; Vascular toxicity; Zebrafish

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peixe-Zebra / Fosfatidilinositol 3-Quinases Limite: Animals Idioma: En Revista: Comp Biochem Physiol C Toxicol Pharmacol Assunto da revista: FARMACOLOGIA / TOXICOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de publicação: Estados Unidos

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