Mice possess a more limited natural antihuman factor VIII antibody repertoire than humans that is produced disproportionately by marginal zone B cells.

Cormier, Matthew; Burnett, Erin; Mo, Aomei; Notley, Colleen; Tijet, Nathalie; Christie-Holmes, Natasha; Hough, Christine; Lillicrap, David

Cormier, Matthew; Burnett, Erin; Mo, Aomei; Notley, Colleen; Tijet, Nathalie; Christie-Holmes, Natasha; Hough, Christine; Lillicrap, David.

Afiliação

Cormier M; Department of Pathology and Molecular Medicine, Queen's University, Kingston, Ontario, Canada. Electronic address: Matt.cormier@queensu.ca.
Burnett E; Department of Pathology and Molecular Medicine, Queen's University, Kingston, Ontario, Canada.
Mo A; Department of Pathology and Molecular Medicine, Queen's University, Kingston, Ontario, Canada.
Notley C; Department of Pathology and Molecular Medicine, Queen's University, Kingston, Ontario, Canada.
Tijet N; Department of Pathology and Molecular Medicine, Queen's University, Kingston, Ontario, Canada.
Christie-Holmes N; Emerging & Pandemic Infections Consortium, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Hough C; Department of Pathology and Molecular Medicine, Queen's University, Kingston, Ontario, Canada.
Lillicrap D; Department of Pathology and Molecular Medicine, Queen's University, Kingston, Ontario, Canada. Electronic address: david.lillicrap@queensu.ca.

J Thromb Haemost ; 22(1): 76-89, 2024 Jan.

Article em En | MEDLINE | ID: mdl-37678547

Assuntos

Fator VIII; Hemofilia A; Adulto; Humanos; Camundongos; Animais; Fator VIII/metabolismo; Imunoglobulina G; Anticorpos Neutralizantes; Imunoglobulina M

Palavras-chave

B-lymphocytes; autoantibodies; factor V; factor VIII; hemophilia A

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator VIII / Hemofilia A Limite: Adult / Animals / Humans Idioma: En Revista: J Thromb Haemost Assunto da revista: HEMATOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de publicação: Reino Unido

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