Ilexchinene, a new seco-ursane triterpenoid from the leaves of Ilex chinensis with therapeutic effect on neuroinflammation by attenuating the MAPK/NF-&#954;B signaling pathway.

Shao, Siyuan; Li, Ruofei; Wang, Kexin; Xia, Wenqi; Cui, Baosong; Li, Shuai

Ilexchinene, a new seco-ursane triterpenoid from the leaves of Ilex chinensis with therapeutic effect on neuroinflammation by attenuating the MAPK/NF-κB signaling pathway.

Shao, Siyuan; Li, Ruofei; Wang, Kexin; Xia, Wenqi; Cui, Baosong; Li, Shuai.

Afiliação

Shao S; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Li R; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Wang K; Key Laboratory of Antibiotic Bioengineering, Ministry of Health, Laboratory of Oncology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Xia W; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Cui B; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Li S; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. Electronic address: lishuai@imm.ac.cn.

Phytomedicine ; 121: 155110, 2023 Dec.

Article em En | MEDLINE | ID: mdl-37776618

Assuntos

Ilex; Triterpenos; Camundongos; Animais; NF-kappa B/metabolismo; Doenças Neuroinflamatórias; Triterpenos/farmacologia; Triterpenos/metabolismo; Ilex/química; Lipopolissacarídeos/farmacologia; Transdução de Sinais; Inflamação/metabolismo; Microglia

Palavras-chave

18,19-seco-ursane triterpenoid; Anti-neuroinflammatory activity; Ilex chinensis; Ilexchinene; MAPK/NF-κB signaling pathway; Neuroinflammation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Triterpenos / Ilex Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Phytomedicine Assunto da revista: TERAPIAS COMPLEMENTARES Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China País de publicação: Alemanha

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