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Ability of Selected Monoterpenes to Reduce Fe(III) Ions Being Pro-Neurodegenerative Factors: Tests Based on a FRAP Reaction Extended to 48 Hours.
Wojtunik-Kulesza, Karolina A; Oniszczuk, Anna.
Afiliação
  • Wojtunik-Kulesza KA; Department of Inorganic Chemistry, Medical University of Lublin, 20-059 Lublin, Poland.
  • Oniszczuk A; Department of Inorganic Chemistry, Medical University of Lublin, 20-059 Lublin, Poland.
Int J Mol Sci ; 25(4)2024 Feb 12.
Article em En | MEDLINE | ID: mdl-38396868
ABSTRACT
Monoterpenes are secondary plant metabolites, and such volatile compounds have antioxidant, antibacterial, antiviral, and enzyme inhibitory properties. These compounds are also able to reduce the potentially pro-neurodegenerative trace metal ions that can be sources of free radicals. One basic method used to evaluate the ability of chemical compounds to reduce Fe(III) is FRAP. To date, most studies based on a FRAP assay were performed within several dozen minutes. However, taking into account the diversity of compounds, it is justified to observe their activity over a much longer period of time. The present study aimed to observe the activity of isopulegol, γ-terpinene, α-terpinene, linalool, carvone, citral, and α-phellandrene over a 48 h period. Our study indicates that the lengthened reaction period enhanced activity from several dozen to several hundred percent. The obtained results also revealed an explicit high correlation of the increase in the activity of compounds with the increase in monoterpene concentration. Due to the hydrophobic character of monoterpenes, the FRAP method was modified by the addition of Tween 20. The highest activity was obtained for α-terpinene and γ-terpinene.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Compostos Férricos / Monoterpenos / Monoterpenos Cicloexânicos Idioma: En Revista: Int J Mol Sci Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Polônia País de publicação: CH / SUIZA / SUÍÇA / SWITZERLAND

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Compostos Férricos / Monoterpenos / Monoterpenos Cicloexânicos Idioma: En Revista: Int J Mol Sci Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Polônia País de publicação: CH / SUIZA / SUÍÇA / SWITZERLAND