Supercharging cancer-fighting T cells with lithium carbonate.

Xu, Yue; Ma, Kaili; Zhang, Lianjun; Li, Guideng

Supercharging cancer-fighting T cells with lithium carbonate.

Xu, Yue; Ma, Kaili; Zhang, Lianjun; Li, Guideng.

Afiliação

Xu Y; National Key Laboratory of Immunity and Inflammation, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou 215123 Jiangsu, China; Key Laboratory of Synthetic Biology Regulatory Elements, Suzhou Institute of Systems Medicine, Chinese Aca
Ma K; National Key Laboratory of Immunity and Inflammation, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou 215123 Jiangsu, China; Key Laboratory of Synthetic Biology Regulatory Elements, Suzhou Institute of Systems Medicine, Chinese Aca
Zhang L; National Key Laboratory of Immunity and Inflammation, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou 215123 Jiangsu, China; Key Laboratory of Synthetic Biology Regulatory Elements, Suzhou Institute of Systems Medicine, Chinese Aca
Li G; National Key Laboratory of Immunity and Inflammation, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou 215123 Jiangsu, China; Key Laboratory of Synthetic Biology Regulatory Elements, Suzhou Institute of Systems Medicine, Chinese Aca

Cell Metab ; 36(3): 463-465, 2024 03 05.

Article em En | MEDLINE | ID: mdl-38447529

ABSTRACT

ABSTRACT

Lactate influences the behavior of various immune cell types. In a recent Nature Immunology study, Ma et al. revealed that lithium carbonate induces monocarboxylate transporter 1 translocation to mitochondria, enhancing cytoplasmic lactate transport into the mitochondria and increasing lactate mitochondrial metabolism, thereby promoting T cell effector function.

Assuntos

Carbonato de Lítio; Neoplasias; Humanos; Carbonato de Lítio/farmacologia; Linfócitos T; Mitocôndrias; Ácido Láctico

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carbonato de Lítio / Neoplasias Limite: Humans Idioma: En Revista: Cell Metab Assunto da revista: METABOLISMO Ano de publicação: 2024 Tipo de documento: Article

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