Chemical Constituents of the Fruits of Cornus Officinalis and Evaluation of their Neuroprotective Activity.
Chem Biodivers
; 21(7): e202400635, 2024 Jul.
Article
em En
| MEDLINE
| ID: mdl-38687253
ABSTRACT
The phytochemical investigation of the fruits of Cornus officinalis yielded a new phenolic acid derivative, neophenolic acid A (1), and a novel flavonoid glycoside, (2R)-naringenin-7-O-ß-(6''-galloyl-glucopyranoside) (2 a), along with six known flavonoid glycosides (2 b-7). Their structures were determined by 1D, 2D NMR and HRESIMS data. The absolute configuration of 1 was established by ECD analysis. Compoundsâ
1-â7 were evaluated for their neuroprotective activities against corticosterone (CORT)-induced injury in PC-12â
cells. Compoundsâ
1, 2 a, 2 b, 5, and 6 exhibited neuroprotective activities against CORT-induced neurotoxicity in PC-12â
cells. The underlying mechanism study suggested that compoundsâ
1, 2 a, 2 b, 5, and 6 were able to attenuate CORT-induced apoptosis and damage, increase the levels of MMP and decrease Ca2+ inward flow in PC-12â
cells.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Apoptose
/
Fármacos Neuroprotetores
/
Cornus
/
Frutas
Limite:
Animals
Idioma:
En
Revista:
Chem Biodivers
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
China
País de publicação:
Suíça