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Association of LIfestyle for BRAin health risk score (LIBRA) and genetic susceptibility with incident dementia and cognitive decline.
Neuffer, Jeanne; Wagner, Maude; Moreno, Elisa; Le Grand, Quentin; Mishra, Aniket; Trégouët, David-Alexandre; Leffondre, Karen; Proust-Lima, Cécile; Foubert-Samier, Alexandra; Berr, Claudine; Tzourio, Christophe; Helmer, Catherine; Debette, Stéphanie; Samieri, Cécilia.
Afiliação
  • Neuffer J; Bordeaux Population Health Research Center, INSERM, University of Bordeaux, Bordeaux, France.
  • Wagner M; Bordeaux Population Health Research Center, INSERM, University of Bordeaux, Bordeaux, France.
  • Moreno E; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.
  • Le Grand Q; Bordeaux Population Health Research Center, INSERM, University of Bordeaux, Bordeaux, France.
  • Mishra A; Bordeaux Population Health Research Center, INSERM, University of Bordeaux, Bordeaux, France.
  • Trégouët DA; Bordeaux Population Health Research Center, INSERM, University of Bordeaux, Bordeaux, France.
  • Leffondre K; Bordeaux Population Health Research Center, INSERM, University of Bordeaux, Bordeaux, France.
  • Proust-Lima C; Bordeaux Population Health Research Center, INSERM, University of Bordeaux, Bordeaux, France.
  • Foubert-Samier A; Clinical and Epidemiological Research Unit, INSERM CIC1401, Bordeaux, France.
  • Berr C; Bordeaux Population Health Research Center, INSERM, University of Bordeaux, Bordeaux, France.
  • Tzourio C; Institut des Maladies Neurodégénératives, Bordeaux University Hospital, Bordeaux, France.
  • Helmer C; University of Montpellier, INSERM, Institute for Neurosciences of Montpellier (INM), Montpellier, France.
  • Debette S; Bordeaux Population Health Research Center, INSERM, University of Bordeaux, Bordeaux, France.
  • Samieri C; Bordeaux Population Health Research Center, INSERM, University of Bordeaux, Bordeaux, France.
Alzheimers Dement ; 20(6): 4250-4259, 2024 06.
Article em En | MEDLINE | ID: mdl-38775256
ABSTRACT

INTRODUCTION:

Evaluating whether genetic susceptibility modifies the impact of lifestyle-related factors on dementia is critical for prevention.

METHODS:

We studied 5170 participants from a French cohort of older persons free of dementia at baseline and followed for up to 17 years. The LIfestyle for BRAin health risk score (LIBRA) including 12 modifiable factors was constructed at baseline (higher score indicating greater risk) and was related to both subsequent cognitive decline and dementia incidence, according to genetic susceptibility to dementia (reflected by the apolipoprotein E [APOE] ε4 allele and a genetic risk score [GRS]).

RESULTS:

The LIBRA was associated with higher dementia incidence, with no significant effect modification by genetics (hazard ratio for one point score = 1.09 [95% confidence interval, 1.05; 1.13]) in APOE ε4 non-carriers and = 1.15 [1.08; 1.22] in carriers; P = 0.15 for interaction). Similar findings were obtained with the GRS and with cognitive decline.

DISCUSSION:

Lifestyle-based prevention may be effective whatever the genetic susceptibility to dementia.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Predisposição Genética para Doença / Demência / Disfunção Cognitiva / Estilo de Vida Limite: Aged / Female / Humans / Male País/Região como assunto: Europa Idioma: En Revista: Alzheimers Dement Ano de publicação: 2024 Tipo de documento: Article País de afiliação: França País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Predisposição Genética para Doença / Demência / Disfunção Cognitiva / Estilo de Vida Limite: Aged / Female / Humans / Male País/Região como assunto: Europa Idioma: En Revista: Alzheimers Dement Ano de publicação: 2024 Tipo de documento: Article País de afiliação: França País de publicação: Estados Unidos