Enhanced long-term potentiation in the anterior cingulate cortex of tree shrew.
Philos Trans R Soc Lond B Biol Sci
; 379(1906): 20230240, 2024 Jul 29.
Article
em En
| MEDLINE
| ID: mdl-38853555
ABSTRACT
Synaptic plasticity is a key cellular model for learning, memory and chronic pain. Most previous studies were carried out in rats and mice, and less is known about synaptic plasticity in non-human primates. In the present study, we used integrative experimental approaches to study long-term potentiation (LTP) in the anterior cingulate cortex (ACC) of adult tree shrews. We found that glutamate is the major excitatory transmitter and α-amino-3-hydroxy-5-methyl-4-isoxazole-propionicacid (AMPA) receptors mediate postsynaptic responses. LTP in tree shrews was greater than that in adult mice and lasted for at least 5 h. N-methyl-d-aspartic acid (NMDA) receptors, Ca2+ influx and adenylyl cyclase 1 (AC1) contributed to tree shrew LTP. Our results suggest that LTP is a major form of synaptic plasticity in the ACC of primate-like animals. This article is part of a discussion meeting issue 'Long-term potentiation 50 years on'.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tupaiidae
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Receptores de N-Metil-D-Aspartato
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Receptores de AMPA
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Potenciação de Longa Duração
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Giro do Cíngulo
Limite:
Animals
Idioma:
En
Revista:
Philos Trans R Soc Lond B Biol Sci
Ano de publicação:
2024
Tipo de documento:
Article
País de publicação:
Reino Unido