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Single-cell sequencing reveals the correlation of aggrephagy signaling and multiple myeloma immune microenvironment composition.
Wang, Xin; Feng, Yu; Wang, Fangfang; Lin, Zhimei; Huang, Jingcao; Li, Qian; Luo, Hongmei; Liu, Xiang; Zhai, Xinyu; Gao, Qianwen; Li, Linfeng; Zhang, Yue; Wen, Jingjing; Zhang, Li; Niu, Ting; Zheng, Yuhuan.
Afiliação
  • Wang X; Department of Hematology, West China Hospital, Sichuan University, Chengdu, China.
  • Feng Y; Department of Hematology, West China Hospital, Sichuan University, Chengdu, China.
  • Wang F; Department of Hematology, West China Hospital, Sichuan University, Chengdu, China.
  • Lin Z; Department of Hematology, West China Hospital, Sichuan University, Chengdu, China.
  • Huang J; Department of Hematology, The Affiliated Hospital of Chengdu University, Chengdu, China.
  • Li Q; Department of Hematology, West China Hospital, Sichuan University, Chengdu, China.
  • Luo H; Department of Hematology, West China Hospital, Sichuan University, Chengdu, China.
  • Liu X; Department of Hematology, West China Hospital, Sichuan University, Chengdu, China.
  • Zhai X; Department of Hematology, West China Hospital, Sichuan University, Chengdu, China.
  • Gao Q; Department of Hematology, West China Hospital, Sichuan University, Chengdu, China.
  • Li L; Department of Hematology, West China Hospital, Sichuan University, Chengdu, China.
  • Zhang Y; School of Life Science, Sichuan University, Chengdu, China.
  • Wen J; Department of Hematology, West China Hospital, Sichuan University, Chengdu, China.
  • Zhang L; Department of Hematology, West China Hospital, Sichuan University, Chengdu, China.
  • Niu T; Department of Hematology, West China Hospital, Sichuan University, Chengdu, China.
  • Zheng Y; Department of Hematology, Mianyang Central Hospital, Mianyang, China.
J Gene Med ; 26(7): e3712, 2024 Jul.
Article em En | MEDLINE | ID: mdl-38949072
ABSTRACT
Aggrephagy, a type of autophagy, degrades the aggregation of misfolded protein in cells. However, the role of aggrephagy in multiple myeloma (MM) has not been fully demonstrated. In this study, we first investigated the correlation between aggrephagy signaling, MM immune microenvironment composition and disease prognosis. Single-cell RNA-seq data, including the expression profiles of 12,187 single cells from seven MM bone marrow (BM) and seven healthy BM samples, were analyzed by non-negative matrix factorization for 44 aggrephagy-related genes. Bulk RNA-seq cohorts from the Gene Expression Omnibus database were used to evaluate the prognostic value of aggrephagy-related immune cell subtypes and predict immune checkpoint blockade immunotherapeutic response in MM. Compared with healthy BM, MM BM exhibited different patterns of aggrephagy-related gene expression. In MM BM, macrophages, CD8+ T cells, B cells and natural killer cells could be grouped into four to nine aggrephagy-related subclusters. The signature of aggrephagy signaling molecule expression in the immune cells correlates with the patient's prognosis. Our investigation provides a novel view of aggrephagy signaling in MM tumor microenvironment cells, which might be a prognostic indicator and potential target for MM treatment.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Análise de Célula Única / Microambiente Tumoral / Mieloma Múltiplo Limite: Humans Idioma: En Revista: J Gene Med Assunto da revista: BIOLOGIA MOLECULAR / GENETICA MEDICA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China País de publicação: ENGLAND / ESCOCIA / GB / GREAT BRITAIN / INGLATERRA / REINO UNIDO / SCOTLAND / UK / UNITED KINGDOM

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Análise de Célula Única / Microambiente Tumoral / Mieloma Múltiplo Limite: Humans Idioma: En Revista: J Gene Med Assunto da revista: BIOLOGIA MOLECULAR / GENETICA MEDICA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China País de publicação: ENGLAND / ESCOCIA / GB / GREAT BRITAIN / INGLATERRA / REINO UNIDO / SCOTLAND / UK / UNITED KINGDOM