Your browser doesn't support javascript.
loading
Rapid detection of lung cancer based on serum Raman spectroscopy and a support vector machine: a case-control study.
Yan, Linfang; Su, Huiting; Liu, Jiafei; Wen, Xiaozheng; Luo, Huaichao; Yin, Yu; Guo, Xiaoqiang.
Afiliação
  • Yan L; Guang'an People's Hospital, Guang'an, Sichuan Province, China.
  • Su H; Guang'an People's Hospital, Guang'an, Sichuan Province, China. huitingsu@yeah.net.
  • Liu J; Guang'an People's Hospital, Guang'an, Sichuan Province, China.
  • Wen X; Guang'an People's Hospital, Guang'an, Sichuan Province, China.
  • Luo H; Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Chengdu, China.
  • Yin Y; Sichuan Institute for Brain Science and Brain-Inspired Intelligence, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China.
  • Guo X; Guang'an People's Hospital, Guang'an, Sichuan Province, China.
BMC Cancer ; 24(1): 791, 2024 Jul 02.
Article em En | MEDLINE | ID: mdl-38956551
ABSTRACT

BACKGROUND:

Early screening and detection of lung cancer is essential for the diagnosis and prognosis of the disease. In this paper, we investigated the feasibility of serum Raman spectroscopy for rapid lung cancer screening.

METHODS:

Raman spectra were collected from 45 patients with lung cancer, 45 with benign lung lesions, and 45 healthy volunteers. And then the support vector machine (SVM) algorithm was applied to build a diagnostic model for lung cancer. Furthermore, 15 independent individuals were sampled for external validation, including 5 lung cancer patients, 5 benign lung lesion patients, and 5 healthy controls.

RESULTS:

The diagnostic sensitivity, specificity, and accuracy were 91.67%, 92.22%, 90.56% (lung cancer vs. healthy control), 92.22%,95.56%,93.33% (benign lung lesion vs. healthy) and 80.00%, 83.33%, 80.83% (lung cancer vs. benign lung lesion), repectively. In the independent validation cohort, our model showed that all the samples were classified correctly.

CONCLUSION:

Therefore, this study demonstrates that the serum Raman spectroscopy analysis technique combined with the SVM algorithm has great potential for the noninvasive detection of lung cancer.
Assuntos
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Análise Espectral Raman / Máquina de Vetores de Suporte / Neoplasias Pulmonares Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: BMC Cancer Assunto da revista: NEOPLASIAS Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China País de publicação: ENGLAND / ESCOCIA / GB / GREAT BRITAIN / INGLATERRA / REINO UNIDO / SCOTLAND / UK / UNITED KINGDOM

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Análise Espectral Raman / Máquina de Vetores de Suporte / Neoplasias Pulmonares Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: BMC Cancer Assunto da revista: NEOPLASIAS Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China País de publicação: ENGLAND / ESCOCIA / GB / GREAT BRITAIN / INGLATERRA / REINO UNIDO / SCOTLAND / UK / UNITED KINGDOM